Key changes in the future clinical application of ultra-high dose rate radiotherapy

Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer...

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Detalles Bibliográficos
Autores principales: Lin, Binwei, Fan, Mi, Niu, Tingting, Liang, Yuwen, Xu, Haonan, Tang, Wenqiang, Du, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628486/
https://www.ncbi.nlm.nih.gov/pubmed/37941555
http://dx.doi.org/10.3389/fonc.2023.1244488
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author Lin, Binwei
Fan, Mi
Niu, Tingting
Liang, Yuwen
Xu, Haonan
Tang, Wenqiang
Du, Xiaobo
author_facet Lin, Binwei
Fan, Mi
Niu, Tingting
Liang, Yuwen
Xu, Haonan
Tang, Wenqiang
Du, Xiaobo
author_sort Lin, Binwei
collection PubMed
description Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer and retain the anti-tumor effect. An important feature of FLASH-RT is that an extremely high dose rate leads to an extremely short treatment time; therefore, in clinical applications, the steps of radiotherapy may need to be adjusted. In this review, we discuss the selection of indications, simulations, target delineation, selection of radiotherapy technologies, and treatment plan evaluation for FLASH-RT to provide a theoretical basis for future research.
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spelling pubmed-106284862023-11-08 Key changes in the future clinical application of ultra-high dose rate radiotherapy Lin, Binwei Fan, Mi Niu, Tingting Liang, Yuwen Xu, Haonan Tang, Wenqiang Du, Xiaobo Front Oncol Oncology Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer and retain the anti-tumor effect. An important feature of FLASH-RT is that an extremely high dose rate leads to an extremely short treatment time; therefore, in clinical applications, the steps of radiotherapy may need to be adjusted. In this review, we discuss the selection of indications, simulations, target delineation, selection of radiotherapy technologies, and treatment plan evaluation for FLASH-RT to provide a theoretical basis for future research. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10628486/ /pubmed/37941555 http://dx.doi.org/10.3389/fonc.2023.1244488 Text en Copyright © 2023 Lin, Fan, Niu, Liang, Xu, Tang and Du https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lin, Binwei
Fan, Mi
Niu, Tingting
Liang, Yuwen
Xu, Haonan
Tang, Wenqiang
Du, Xiaobo
Key changes in the future clinical application of ultra-high dose rate radiotherapy
title Key changes in the future clinical application of ultra-high dose rate radiotherapy
title_full Key changes in the future clinical application of ultra-high dose rate radiotherapy
title_fullStr Key changes in the future clinical application of ultra-high dose rate radiotherapy
title_full_unstemmed Key changes in the future clinical application of ultra-high dose rate radiotherapy
title_short Key changes in the future clinical application of ultra-high dose rate radiotherapy
title_sort key changes in the future clinical application of ultra-high dose rate radiotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628486/
https://www.ncbi.nlm.nih.gov/pubmed/37941555
http://dx.doi.org/10.3389/fonc.2023.1244488
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