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Report on a case of liver-originating malignant melanoma of unknown primary
Malignant melanoma (MM) frequently occurs in the skin or mucosa, whereas malignant melanoma of unknown primary (MUP) is diagnosed in patients with lymph nodes or visceral organs as the site of origin, where it is challenging to detect the primary lesion by comprehensive examination. MUP is possibly...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628584/ https://www.ncbi.nlm.nih.gov/pubmed/37941789 http://dx.doi.org/10.1515/biol-2022-0750 |
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author | Yuan, Zheng Guo, Hai-yan Lu, Wei-ting Wang, Yao-hui He, Jing Zhang, Fan Che, Jun-yong Qiao, Fei |
author_facet | Yuan, Zheng Guo, Hai-yan Lu, Wei-ting Wang, Yao-hui He, Jing Zhang, Fan Che, Jun-yong Qiao, Fei |
author_sort | Yuan, Zheng |
collection | PubMed |
description | Malignant melanoma (MM) frequently occurs in the skin or mucosa, whereas malignant melanoma of unknown primary (MUP) is diagnosed in patients with lymph nodes or visceral organs as the site of origin, where it is challenging to detect the primary lesion by comprehensive examination. MUP is possibly related to the spontaneous regression of the primary lesion. In addition, primary hepatic melanoma (PHM) usually refers to the primary MM occurring in the liver, with no typical primary lesions and no manifestations of tumor metastasis. A 61-year-old male patient with liver as the site of origin was diagnosed with MM by Melan-A, HMB-45, and S-100 immunohistochemistry staining of liver biopsy tissue. Based on a comprehensive examination, no basis was found for melanoma in sites such as the skin, mucosa, five sense organs, brain, digestive tract, respiratory tract, or genitalia, and the patient was subsequently diagnosed with MUP. MMs require a comprehensive inspection, beginning with the liver, to search for the primary lesion; if the primary lesion is not found, the possibility of PHM or MUP should be considered. |
format | Online Article Text |
id | pubmed-10628584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-106285842023-11-08 Report on a case of liver-originating malignant melanoma of unknown primary Yuan, Zheng Guo, Hai-yan Lu, Wei-ting Wang, Yao-hui He, Jing Zhang, Fan Che, Jun-yong Qiao, Fei Open Life Sci Case Report Malignant melanoma (MM) frequently occurs in the skin or mucosa, whereas malignant melanoma of unknown primary (MUP) is diagnosed in patients with lymph nodes or visceral organs as the site of origin, where it is challenging to detect the primary lesion by comprehensive examination. MUP is possibly related to the spontaneous regression of the primary lesion. In addition, primary hepatic melanoma (PHM) usually refers to the primary MM occurring in the liver, with no typical primary lesions and no manifestations of tumor metastasis. A 61-year-old male patient with liver as the site of origin was diagnosed with MM by Melan-A, HMB-45, and S-100 immunohistochemistry staining of liver biopsy tissue. Based on a comprehensive examination, no basis was found for melanoma in sites such as the skin, mucosa, five sense organs, brain, digestive tract, respiratory tract, or genitalia, and the patient was subsequently diagnosed with MUP. MMs require a comprehensive inspection, beginning with the liver, to search for the primary lesion; if the primary lesion is not found, the possibility of PHM or MUP should be considered. De Gruyter 2023-10-23 /pmc/articles/PMC10628584/ /pubmed/37941789 http://dx.doi.org/10.1515/biol-2022-0750 Text en © 2023 the author(s), published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Case Report Yuan, Zheng Guo, Hai-yan Lu, Wei-ting Wang, Yao-hui He, Jing Zhang, Fan Che, Jun-yong Qiao, Fei Report on a case of liver-originating malignant melanoma of unknown primary |
title | Report on a case of liver-originating malignant melanoma of unknown primary |
title_full | Report on a case of liver-originating malignant melanoma of unknown primary |
title_fullStr | Report on a case of liver-originating malignant melanoma of unknown primary |
title_full_unstemmed | Report on a case of liver-originating malignant melanoma of unknown primary |
title_short | Report on a case of liver-originating malignant melanoma of unknown primary |
title_sort | report on a case of liver-originating malignant melanoma of unknown primary |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628584/ https://www.ncbi.nlm.nih.gov/pubmed/37941789 http://dx.doi.org/10.1515/biol-2022-0750 |
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