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A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case
Pancreatic cancer (PC) is a highly aggressive malignancy, often accompanied by liver metastases as a common manifestation. While palliative chemotherapy remains the mainstay treatment for liver metastatic PC, local treatment approaches have gained attention, especially for patients with oligometasta...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628600/ https://www.ncbi.nlm.nih.gov/pubmed/37942384 http://dx.doi.org/10.7759/cureus.46671 |
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author | Ikuta, Shinichi Nakajima, Takayoshi Aihara, Tsukasa Fujikawa, Masataka Yamanaka, Naoki |
author_facet | Ikuta, Shinichi Nakajima, Takayoshi Aihara, Tsukasa Fujikawa, Masataka Yamanaka, Naoki |
author_sort | Ikuta, Shinichi |
collection | PubMed |
description | Pancreatic cancer (PC) is a highly aggressive malignancy, often accompanied by liver metastases as a common manifestation. While palliative chemotherapy remains the mainstay treatment for liver metastatic PC, local treatment approaches have gained attention, especially for patients with oligometastasis who exhibit a positive response to chemotherapy. This case report illustrates the successful application of a liver-first strategy in a 79-year-old male diagnosed with liver oligometastatic PC, originating in the pancreatic tail. The strategy encompassed percutaneous microwave ablation for liver metastases, followed by FOLFIRINOX (5-fluorouracil, folic acid, irinotecan, and oxaliplatin) chemotherapy, and subsequent primary tumor resection. The patient has remained disease-free for over a year post-surgery. This multidisciplinary approach may hold promise for selected patients with liver oligometastatic PC, although further research and case studies are needed for comprehensive evaluation. |
format | Online Article Text |
id | pubmed-10628600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-106286002023-11-08 A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case Ikuta, Shinichi Nakajima, Takayoshi Aihara, Tsukasa Fujikawa, Masataka Yamanaka, Naoki Cureus Gastroenterology Pancreatic cancer (PC) is a highly aggressive malignancy, often accompanied by liver metastases as a common manifestation. While palliative chemotherapy remains the mainstay treatment for liver metastatic PC, local treatment approaches have gained attention, especially for patients with oligometastasis who exhibit a positive response to chemotherapy. This case report illustrates the successful application of a liver-first strategy in a 79-year-old male diagnosed with liver oligometastatic PC, originating in the pancreatic tail. The strategy encompassed percutaneous microwave ablation for liver metastases, followed by FOLFIRINOX (5-fluorouracil, folic acid, irinotecan, and oxaliplatin) chemotherapy, and subsequent primary tumor resection. The patient has remained disease-free for over a year post-surgery. This multidisciplinary approach may hold promise for selected patients with liver oligometastatic PC, although further research and case studies are needed for comprehensive evaluation. Cureus 2023-10-08 /pmc/articles/PMC10628600/ /pubmed/37942384 http://dx.doi.org/10.7759/cureus.46671 Text en Copyright © 2023, Ikuta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Gastroenterology Ikuta, Shinichi Nakajima, Takayoshi Aihara, Tsukasa Fujikawa, Masataka Yamanaka, Naoki A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title | A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title_full | A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title_fullStr | A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title_full_unstemmed | A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title_short | A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case |
title_sort | liver-first approach using ablation for oligometastatic pancreatic cancer: a report of a successful case |
topic | Gastroenterology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628600/ https://www.ncbi.nlm.nih.gov/pubmed/37942384 http://dx.doi.org/10.7759/cureus.46671 |
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