A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress

Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell carcinoma (RCC). Most of the therapeutic agents mediate cancer cell death through increased oxidative stress. Induction of c-Met in renal cancer cells promotes the activation of redox-sensitive transcription facto...

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Detalles Bibliográficos
Autores principales: Rawat, Laxminarayan, Balan, Murugabaskar, Sasamoto, Yuzuru, Sabarwal, Akash, Pal, Soumitro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628632/
https://www.ncbi.nlm.nih.gov/pubmed/37898101
http://dx.doi.org/10.1016/j.redox.2023.102945

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