Cargando…

Living myocardial slices for the study of nucleic acid-based therapies

Gene therapy based on viral vectors offers great potential for the study and the treatment of cardiac diseases. Here we explore the use of Living Myocardial Slices (LMS) as a platform for nucleic acid-based therapies. Rat LMS and Adeno-Associated viruses (AAV) were used to optimise and analyse gene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nunez-Toldra, R., Del Canizo, A., Secco, I., Nicastro, L., Giacca, M., Terracciano, C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628718/ https://www.ncbi.nlm.nih.gov/pubmed/37941724 http://dx.doi.org/10.3389/fbioe.2023.1275945

Ejemplares similares

Mechanosensitive molecular mechanisms of myocardial fibrosis in living myocardial slices
por: Nunez‐Toldra, Raquel, et al.
Publicado: (2022)

Editorial: Synthetic Nucleic Acids for Expanding Genetic Codes and Probing Living Cells
por: O'Donoghue, Patrick, et al.
Publicado: (2021)

CaMKII inhibition reduces arrhythmogenic Ca(2+) events in subendocardial cryoinjured rat living myocardial slices
por: Dries, Eef, et al.
Publicado: (2021)

Editorial: Non-viral vectors for gene therapy/nucleic acid delivery
por: Poddar, Arpita, et al.
Publicado: (2023)

At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids
por: Uludag, Hasan, et al.
Publicado: (2019)

Electrical and Electrochemical Monitoring of Nucleic Acid Amplification
por: Goda, Tatsuro, et al.
Publicado: (2015)

Interfacing Neural Network Components and Nucleic Acids
por: Lissek, Thomas
Publicado: (2017)

Nucleic acid vaccination strategies for ovarian cancer
por: Saha, Chayanika, et al.
Publicado: (2022)

DNA Functional Nanomaterials for Controlled Delivery of Nucleic Acid-Based Drugs
por: Lv, Zhaoyue, et al.
Publicado: (2021)

Editorial: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, and Biosensors
por: Jouha, Jabrane, et al.
Publicado: (2022)

Editorial: Molecular and nanoscale engineering of nucleic acid theranostics and vaccines
por: Tan, Xiaohong, et al.
Publicado: (2023)

A portable system for economical nucleic acid amplification testing
por: Dong, Hui, et al.
Publicado: (2023)

Effects of Different Lengths of a Nucleic Acid Binding Region and Bound Nucleic Acids on the Phase Behavior and Purification Process of HBcAg Virus-Like Particles
por: Valentic, Angela, et al.
Publicado: (2022)

Novel Decellularization Method for Tissue Slices
por: Narciso, Maria, et al.
Publicado: (2022)

Paper-Based Devices for Capturing Exosomes and Exosomal Nucleic Acids From Biological Samples
por: Lai, Chi-Hung, et al.
Publicado: (2022)

Assay methods based on proximity-enhanced reactions for detecting non-nucleic acid molecules
por: Park, Ye Seop, et al.
Publicado: (2023)

PEGylation and folic-acid functionalization of cationic lipoplexes—Improved nucleic acid transfer into cancer cells
por: Hoffmann, Marco, et al.
Publicado: (2022)

Discovering the Potential of Dental Pulp Stem Cells for Corneal Endothelial Cell Production: A Proof of Concept
por: Bosch, Begoña M., et al.
Publicado: (2021)

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects
por: Chen, Xingyu, et al.
Publicado: (2021)

Nucleic acid amplification strategies for volume-amplified magnetic nanoparticle detection assay
por: Huang, Zhongchao, et al.
Publicado: (2022)

Recent advances in PCR-free nucleic acid detection for SARS-COV-2
por: Ma, Xiaowei, et al.
Publicado: (2022)

Simultaneous Isolation of Circulating Nucleic Acids and EV-Associated Protein Biomarkers From Unprocessed Plasma Using an AC Electrokinetics-Based Platform
por: Hinestrosa, Juan Pablo, et al.
Publicado: (2020)

Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective
por: Zhu, Gan, et al.
Publicado: (2022)

An integrated digital PCR system with high universality and low cost for nucleic acid detection
por: Wang, Kangning, et al.
Publicado: (2022)

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications
por: Stojanov, Spase, et al.
Publicado: (2020)

Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review
por: He, Ziyu, et al.
Publicado: (2022)

Rapid on-site nucleic acid testing: On-chip sample preparation, amplification, and detection, and their integration into all-in-one systems
por: Wang, Jingwen, et al.
Publicado: (2023)

A miniaturized and integrated dual-channel fluorescence module for multiplex real-time PCR in the portable nucleic acid detection system
por: Fang, Yile, et al.
Publicado: (2022)

Asymmetric stem-loop–mediated isothermal amplification of nucleic acids for DNA diagnostic assays by simple modification of canonical PCR primers
por: Mao, Rui, et al.
Publicado: (2022)

Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways
por: Lohchania, Brijesh, et al.
Publicado: (2023)

Simultaneous Nucleic Acids Detection and Elimination of Carryover Contamination With Nanoparticles-Based Biosensor- and Antarctic Thermal Sensitive Uracil-DNA-Glycosylase-Supplemented Polymerase Spiral Reaction
por: Wang, Yi, et al.
Publicado: (2019)

A Fast, Visual, and Instrument-free Platform Involving Rapid DNA Extraction, Chemical Heating, and Recombinase Aided Amplification for On-Site Nucleic Acid Detection
por: Wang, Xiao Fu, et al.
Publicado: (2021)

A tunable physiomimetic stretch system evaluated with precision cut lung slices and recellularized human lung scaffolds
por: Rosmark, Oskar, et al.
Publicado: (2022)

mRNA therapy for myocardial infarction: A review of targets and delivery vehicles
por: Wang, Xinming, et al.
Publicado: (2022)

Adenoviral VEGF-D(ΔN ΔC) gene therapy for myocardial ischemia
por: Pajula, Juho, et al.
Publicado: (2022)

Novel Strategies for Efficient Production and Delivery of Live Biotherapeutics and Biotechnological Uses of Lactococcus lactis: The Lactic Acid Bacterium Model
por: Tavares, Laísa M., et al.
Publicado: (2020)

Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy
por: Yue, Tian, et al.
Publicado: (2022)

Cardiac Fibroblasts and Myocardial Regeneration
por: Chen, Wangping, et al.
Publicado: (2021)

Engineered Bacteria-Based Living Materials for Biotherapeutic Applications
por: Omer, Rabia, et al.
Publicado: (2022)

Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction
por: Gara, Edit, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_71ogtighp8ir14nkjjvfpfgcmr