Cargando…

Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer

BACKGROUND: Interferon-γ (IFN-γ) is a key cytokine with diverse biological functions, including antiviral defense, antitumor activity, immune regulation, and modulation of cellular processes. Nonetheless, its role in pancreatic cancer (PC) therapy remains debated. Therefore, it is worthwhile to expl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xu, Yuan, Qihang, Guan, Hewen, Shi, Xueying, Sun, Jiaao, Wu, Zhiqiang, Ren, Jie, Xia, Shilin, Shang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628740/ https://www.ncbi.nlm.nih.gov/pubmed/37941546 http://dx.doi.org/10.3389/fonc.2023.1227606

Ejemplares similares

Integrated single-cell and bulk RNA sequencing revealed the molecular characteristics and prognostic roles of neutrophils in pancreatic cancer
por: Zhang, Biao, et al.
Publicado: (2023)

Determination and characterization of molecular heterogeneity and precision medicine strategies of patients with pancreatic cancer and pancreatic neuroendocrine tumor based on oxidative stress and mitochondrial dysfunction-related genes
por: Cui, Yougang, et al.
Publicado: (2023)

Molecular characteristics and therapeutic implications of Toll-like receptor signaling pathway in melanoma
por: Guan, Hewen, et al.
Publicado: (2023)

T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?
por: Zhou, Qi, et al.
Publicado: (2020)

Identification of the γ-glutamyl cycle as a novel therapeutic target and 5-oxoproline as a new biomarker for diagnosing pancreatic cancer
por: Wang, Weijia, et al.
Publicado: (2023)

Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies
por: Xu, Ruiyuan, et al.
Publicado: (2020)

Editorial: The Microenvironment in Pancreatic Cancer and Therapeutic Strategies Targeting Microenvironment
por: Duan, Wanxing, et al.
Publicado: (2022)

Identification and characterization of a novel molecular classification incorporating oxidative stress and metabolism-related genes for stomach adenocarcinoma in the framework of predictive, preventive, and personalized medicine
por: Dong, Ying, et al.
Publicado: (2023)

Malignant ascites in pancreatic cancer: Pathophysiology, diagnosis, molecular characterization, and therapeutic strategies
por: Han, Margaret Y., et al.
Publicado: (2023)

Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome
por: Juiz, Natalia Anahi, et al.
Publicado: (2019)

Gene Coexpression Network Characterizing Microenvironmental Heterogeneity and Intercellular Communication in Pancreatic Ductal Adenocarcinoma: Implications of Prognostic Significance and Therapeutic Target
por: Wu, Chengsi, et al.
Publicado: (2022)

WGCNA identification of TLR7 as a novel diagnostic biomarker, progression and prognostic indicator, and immunotherapeutic target for stomach adenocarcinoma
por: Yuan, Qihang, et al.
Publicado: (2021)

Heterogeneity of glycan biomarker clusters as an indicator of recurrence in pancreatic cancer
por: Wisniewski, Luke, et al.
Publicado: (2023)

Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?
por: Ferreira, Roseane Guimarães, et al.
Publicado: (2021)

Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma
por: Ren, Zhangyong, et al.
Publicado: (2023)

Editorial: Gastrointestinal Tumor Heterogeneity and Related Anti-Cancer Strategies
por: Liao, Rui, et al.
Publicado: (2022)

Network Control Models With Personalized Genomics Data for Understanding Tumor Heterogeneity in Cancer
por: Yan, Jipeng, et al.
Publicado: (2022)

Comprehensive analysis of cuproptosis-related long non-coding RNA signature and personalized therapeutic strategy of breast cancer patients
por: Guo, Qiaonan, et al.
Publicado: (2022)

Risk Factors and Therapeutic Targets in Pancreatic Cancer
por: Wörmann, Sonja Maria, et al.
Publicado: (2013)

The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
por: Albahde, Mugahed Abdullah Hasan, et al.
Publicado: (2021)

Neutrophils in pancreatic cancer: Potential therapeutic targets
por: Jiang, Wenkai, et al.
Publicado: (2022)

Editorial: Targeting Pancreatic Cancer: Strategies and Hopes
por: Manu, Kanjoormana Aryan, et al.
Publicado: (2022)

Comprehensive characterization of extracellular matrix-related genes in PAAD identified a novel prognostic panel related to clinical outcomes and immune microenvironment: A silico analysis with in vivo and vitro validation
por: Chen, Xu, et al.
Publicado: (2022)

Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies
por: Harland, Abigail, et al.
Publicado: (2021)

MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma
por: Chirravuri-Venkata, Ramakanth, et al.
Publicado: (2023)

Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations
por: Färber, Benedikt, et al.
Publicado: (2023)

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities
por: Johnson, Amanda L., et al.
Publicado: (2022)

Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
por: Liu, Dahai, et al.
Publicado: (2023)

Canine Cancer: Strategies in Experimental Therapeutics
por: Thamm, Douglas H.
Publicado: (2019)

The Microbiome Tumor Axis: How the Microbiome Could Contribute to Clonal Heterogeneity and Disease Outcome in Pancreatic Cancer
por: Basu, Meghna, et al.
Publicado: (2021)

Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
por: Comba, Andrea, et al.
Publicado: (2021)

UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis
por: Luo, Yiqiao, et al.
Publicado: (2022)

The prospect of tumor microenvironment-modulating therapeutical strategies
por: Eulberg, Dirk, et al.
Publicado: (2022)

Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
por: Sparks, Rachel, et al.
Publicado: (2017)

Emerging roles of platelets in cancer biology and their potential as therapeutic targets
por: Wang, Lei, et al.
Publicado: (2022)

Reveal the Heterogeneity in the Tumor Microenvironment of Pancreatic Cancer and Analyze the Differences in Prognosis and Immunotherapy Responses of Distinct Immune Subtypes
por: Wang, Xiaoqin, et al.
Publicado: (2022)

Transcriptomic Analyses and Potential Therapeutic Targets of Pancreatic Cancer With Concomitant Diabetes
por: Xu, Tingting, et al.
Publicado: (2020)

The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy
por: Principe, Daniel R., et al.
Publicado: (2021)

Editorial: Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments
por: Timofeev, Oleg
Publicado: (2021)

A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo
por: Wang, Zhizhou, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5lhgctglmclvihrhd0p5c4ucii