Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis

INTRODUCTION: Optic neuritis (ON) is often an early sign of multiple sclerosis (MS), and recent studies show a link between HIF-1 pathway activation and inflammation. This study aimed to determine if inhibition of the HIF-1 pathway using the HIF-1a antagonist acriflavine (ACF) can reduce clinical pr...

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Detalles Bibliográficos
Autores principales: Anders, Jeffrey J., Elwood, Benjamin W., Kardon, Randy H., Gramlich, Oliver W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628762/
https://www.ncbi.nlm.nih.gov/pubmed/37942317
http://dx.doi.org/10.3389/fimmu.2023.1271118

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