Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -...

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Detalles Bibliográficos
Autores principales: Alshammari, Mohammed B., Aly, Ashraf A., Ahmad, Akil, Brown, Alan B., Mohamed, Asmaa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628897/
https://www.ncbi.nlm.nih.gov/pubmed/37942448
http://dx.doi.org/10.1039/d3ra06054c
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author Alshammari, Mohammed B.
Aly, Ashraf A.
Ahmad, Akil
Brown, Alan B.
Mohamed, Asmaa H.
author_facet Alshammari, Mohammed B.
Aly, Ashraf A.
Ahmad, Akil
Brown, Alan B.
Mohamed, Asmaa H.
author_sort Alshammari, Mohammed B.
collection PubMed
description Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years.
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spelling pubmed-106288972023-11-08 Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review Alshammari, Mohammed B. Aly, Ashraf A. Ahmad, Akil Brown, Alan B. Mohamed, Asmaa H. RSC Adv Chemistry Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years. The Royal Society of Chemistry 2023-11-07 /pmc/articles/PMC10628897/ /pubmed/37942448 http://dx.doi.org/10.1039/d3ra06054c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Alshammari, Mohammed B.
Aly, Ashraf A.
Ahmad, Akil
Brown, Alan B.
Mohamed, Asmaa H.
Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title_full Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title_fullStr Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title_full_unstemmed Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title_short Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
title_sort recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628897/
https://www.ncbi.nlm.nih.gov/pubmed/37942448
http://dx.doi.org/10.1039/d3ra06054c
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