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Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

BACKGROUND: Ulcerative colitis (UC) is a progressive chronic inflammatory disorder. Neutrophils play a critical role in regulating intestinal mucosal homeostasis in UC. Spleen tyrosine kinase (Syk) is involved in several inflammatory diseases. Here, we evaluated the effects and underlying mechanisms...

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Detalles Bibliográficos
Autores principales:	Zhu, Fengqin, Jing, Dehuai, Zhou, Huihui, Hu, Zongjing, Wang, Yan, Jin, Guiyuan, Yang, Yonghong, Zhou, Guangxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628969/ https://www.ncbi.nlm.nih.gov/pubmed/37941642 http://dx.doi.org/10.1093/pcmedi/pbad025

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