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A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628982/ https://www.ncbi.nlm.nih.gov/pubmed/37941962 http://dx.doi.org/10.1039/d3na00459g |
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author | Joshi, Arti Acharya, Sobhna Devi, Neeta Gupta, Ruby Sharma, Deepika Singh, Monika |
author_facet | Joshi, Arti Acharya, Sobhna Devi, Neeta Gupta, Ruby Sharma, Deepika Singh, Monika |
author_sort | Joshi, Arti |
collection | PubMed |
description | Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by adjusting the stereochemical and physicochemical features of POMs. In the present report a polyoxomolybdate (POMo) based organic–inorganic hybrid solid (C(6)H(16)N)(C(6)H(15)N)(2)[Mo(8)O(26)]·3H(2)O, solid 1, has been synthesized and its antitumoral activities have been investigated against three cancer cell lines namely, A549 (Lung cancer), HepG2 (Liver cancer), and MCF-7 (Breast cancer) with IC50 values 56.2 μmol L(−1), 57.3 μmol L(−1), and 55.2 μmol L(−1) respectively. The structural characterization revealed that solid 1 consists of an octa molybdate-type cluster connected by three triethylamine molecules via hydrogen bonding interactions. The electron microscopy analysis suggests the nanocapsule-like morphology of solid 1 in the size range of 50–70 nm. The UV-vis absorption spectra were used to assess the binding ability of synthesized POM-based solid 1 to calf thymus DNA (ctDNA), which further explained the binding interaction between POMo and ctDNA and the binding constant was calculated to be 2.246 × 10(3) giving evidence of groove binding. |
format | Online Article Text |
id | pubmed-10628982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-106289822023-11-08 A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent Joshi, Arti Acharya, Sobhna Devi, Neeta Gupta, Ruby Sharma, Deepika Singh, Monika Nanoscale Adv Chemistry Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by adjusting the stereochemical and physicochemical features of POMs. In the present report a polyoxomolybdate (POMo) based organic–inorganic hybrid solid (C(6)H(16)N)(C(6)H(15)N)(2)[Mo(8)O(26)]·3H(2)O, solid 1, has been synthesized and its antitumoral activities have been investigated against three cancer cell lines namely, A549 (Lung cancer), HepG2 (Liver cancer), and MCF-7 (Breast cancer) with IC50 values 56.2 μmol L(−1), 57.3 μmol L(−1), and 55.2 μmol L(−1) respectively. The structural characterization revealed that solid 1 consists of an octa molybdate-type cluster connected by three triethylamine molecules via hydrogen bonding interactions. The electron microscopy analysis suggests the nanocapsule-like morphology of solid 1 in the size range of 50–70 nm. The UV-vis absorption spectra were used to assess the binding ability of synthesized POM-based solid 1 to calf thymus DNA (ctDNA), which further explained the binding interaction between POMo and ctDNA and the binding constant was calculated to be 2.246 × 10(3) giving evidence of groove binding. RSC 2023-10-06 /pmc/articles/PMC10628982/ /pubmed/37941962 http://dx.doi.org/10.1039/d3na00459g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Joshi, Arti Acharya, Sobhna Devi, Neeta Gupta, Ruby Sharma, Deepika Singh, Monika A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title | A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title_full | A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title_fullStr | A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title_full_unstemmed | A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title_short | A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
title_sort | polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628982/ https://www.ncbi.nlm.nih.gov/pubmed/37941962 http://dx.doi.org/10.1039/d3na00459g |
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