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A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent

Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by...

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Autores principales: Joshi, Arti, Acharya, Sobhna, Devi, Neeta, Gupta, Ruby, Sharma, Deepika, Singh, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628982/
https://www.ncbi.nlm.nih.gov/pubmed/37941962
http://dx.doi.org/10.1039/d3na00459g
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author Joshi, Arti
Acharya, Sobhna
Devi, Neeta
Gupta, Ruby
Sharma, Deepika
Singh, Monika
author_facet Joshi, Arti
Acharya, Sobhna
Devi, Neeta
Gupta, Ruby
Sharma, Deepika
Singh, Monika
author_sort Joshi, Arti
collection PubMed
description Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by adjusting the stereochemical and physicochemical features of POMs. In the present report a polyoxomolybdate (POMo) based organic–inorganic hybrid solid (C(6)H(16)N)(C(6)H(15)N)(2)[Mo(8)O(26)]·3H(2)O, solid 1, has been synthesized and its antitumoral activities have been investigated against three cancer cell lines namely, A549 (Lung cancer), HepG2 (Liver cancer), and MCF-7 (Breast cancer) with IC50 values 56.2 μmol L(−1), 57.3 μmol L(−1), and 55.2 μmol L(−1) respectively. The structural characterization revealed that solid 1 consists of an octa molybdate-type cluster connected by three triethylamine molecules via hydrogen bonding interactions. The electron microscopy analysis suggests the nanocapsule-like morphology of solid 1 in the size range of 50–70 nm. The UV-vis absorption spectra were used to assess the binding ability of synthesized POM-based solid 1 to calf thymus DNA (ctDNA), which further explained the binding interaction between POMo and ctDNA and the binding constant was calculated to be 2.246 × 10(3) giving evidence of groove binding.
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spelling pubmed-106289822023-11-08 A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent Joshi, Arti Acharya, Sobhna Devi, Neeta Gupta, Ruby Sharma, Deepika Singh, Monika Nanoscale Adv Chemistry Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by adjusting the stereochemical and physicochemical features of POMs. In the present report a polyoxomolybdate (POMo) based organic–inorganic hybrid solid (C(6)H(16)N)(C(6)H(15)N)(2)[Mo(8)O(26)]·3H(2)O, solid 1, has been synthesized and its antitumoral activities have been investigated against three cancer cell lines namely, A549 (Lung cancer), HepG2 (Liver cancer), and MCF-7 (Breast cancer) with IC50 values 56.2 μmol L(−1), 57.3 μmol L(−1), and 55.2 μmol L(−1) respectively. The structural characterization revealed that solid 1 consists of an octa molybdate-type cluster connected by three triethylamine molecules via hydrogen bonding interactions. The electron microscopy analysis suggests the nanocapsule-like morphology of solid 1 in the size range of 50–70 nm. The UV-vis absorption spectra were used to assess the binding ability of synthesized POM-based solid 1 to calf thymus DNA (ctDNA), which further explained the binding interaction between POMo and ctDNA and the binding constant was calculated to be 2.246 × 10(3) giving evidence of groove binding. RSC 2023-10-06 /pmc/articles/PMC10628982/ /pubmed/37941962 http://dx.doi.org/10.1039/d3na00459g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Joshi, Arti
Acharya, Sobhna
Devi, Neeta
Gupta, Ruby
Sharma, Deepika
Singh, Monika
A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title_full A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title_fullStr A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title_full_unstemmed A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title_short A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
title_sort polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628982/
https://www.ncbi.nlm.nih.gov/pubmed/37941962
http://dx.doi.org/10.1039/d3na00459g
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