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Radiation-Associated Breast Angiosarcoma

Radiation-associated breast angiosarcomas are rare following breast-conserving surgery. These angiosarcomas are considered adverse events associated with radiation therapy and are characterized by a high risk of both local and distant recurrence, even after complete resection. Despite this, there is...

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Autores principales: Yoshino, Ryusei, Yoshida, Nana, Ujiie, Nanami, Ito, Akane, Nakatsubo, Masaki, Kamikokura, Yuki, Kitada, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628990/
https://www.ncbi.nlm.nih.gov/pubmed/37942397
http://dx.doi.org/10.7759/cureus.46673
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author Yoshino, Ryusei
Yoshida, Nana
Ujiie, Nanami
Ito, Akane
Nakatsubo, Masaki
Kamikokura, Yuki
Kitada, Masahiro
author_facet Yoshino, Ryusei
Yoshida, Nana
Ujiie, Nanami
Ito, Akane
Nakatsubo, Masaki
Kamikokura, Yuki
Kitada, Masahiro
author_sort Yoshino, Ryusei
collection PubMed
description Radiation-associated breast angiosarcomas are rare following breast-conserving surgery. These angiosarcomas are considered adverse events associated with radiation therapy and are characterized by a high risk of both local and distant recurrence, even after complete resection. Despite this, there is currently no established standard treatment for them. The patient was a 70-year-old woman who had breast-conserving surgery for right breast cancer 10 years before presentation. She was followed up for 10 years after receiving 50 Gy of residual breast irradiation and an aromatase inhibitor for 5 years. During follow-up, a painless purplish area with induration, measuring 10 cm by 5.4 cm, was noted on the right nipple. A skin biopsy confirmed hemangiosarcoma. Treatment included surgery with a 2.0 cm margin from the area, followed by skin excision and total mastectomy. A final diagnosis of radiation-associated breast angiosarcoma was made. Radiation-associated breast angiosarcoma is a rare disease with a poor prognosis that lacks standard treatment. An aggressive skin biopsy should be considered when skin findings such as purpura are seen after breast cancer radiotherapy, as in this case.
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spelling pubmed-106289902023-11-08 Radiation-Associated Breast Angiosarcoma Yoshino, Ryusei Yoshida, Nana Ujiie, Nanami Ito, Akane Nakatsubo, Masaki Kamikokura, Yuki Kitada, Masahiro Cureus Pathology Radiation-associated breast angiosarcomas are rare following breast-conserving surgery. These angiosarcomas are considered adverse events associated with radiation therapy and are characterized by a high risk of both local and distant recurrence, even after complete resection. Despite this, there is currently no established standard treatment for them. The patient was a 70-year-old woman who had breast-conserving surgery for right breast cancer 10 years before presentation. She was followed up for 10 years after receiving 50 Gy of residual breast irradiation and an aromatase inhibitor for 5 years. During follow-up, a painless purplish area with induration, measuring 10 cm by 5.4 cm, was noted on the right nipple. A skin biopsy confirmed hemangiosarcoma. Treatment included surgery with a 2.0 cm margin from the area, followed by skin excision and total mastectomy. A final diagnosis of radiation-associated breast angiosarcoma was made. Radiation-associated breast angiosarcoma is a rare disease with a poor prognosis that lacks standard treatment. An aggressive skin biopsy should be considered when skin findings such as purpura are seen after breast cancer radiotherapy, as in this case. Cureus 2023-10-08 /pmc/articles/PMC10628990/ /pubmed/37942397 http://dx.doi.org/10.7759/cureus.46673 Text en Copyright © 2023, Yoshino et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Yoshino, Ryusei
Yoshida, Nana
Ujiie, Nanami
Ito, Akane
Nakatsubo, Masaki
Kamikokura, Yuki
Kitada, Masahiro
Radiation-Associated Breast Angiosarcoma
title Radiation-Associated Breast Angiosarcoma
title_full Radiation-Associated Breast Angiosarcoma
title_fullStr Radiation-Associated Breast Angiosarcoma
title_full_unstemmed Radiation-Associated Breast Angiosarcoma
title_short Radiation-Associated Breast Angiosarcoma
title_sort radiation-associated breast angiosarcoma
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628990/
https://www.ncbi.nlm.nih.gov/pubmed/37942397
http://dx.doi.org/10.7759/cureus.46673
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