Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

BACKGROUND: Autism spectrum disorder (ASD) has been associated with intrauterine growth restriction (IUGR), but the underlying mechanisms are unclear. RESULTS: We found that the IUGR rat model induced by prenatal caffeine exposure (PCE) showed ASD-like symptoms, accompanied by altered gut microbiota...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Chen, Beidi, Luo, Mingcui, Xie, Lulu, Lu, Mengxi, Lu, Xiaoqian, Zhang, Shuai, Wei, Liyi, Zhou, Xinli, Yao, Baozhen, Wang, Hui, Xu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629055/
https://www.ncbi.nlm.nih.gov/pubmed/37932832
http://dx.doi.org/10.1186/s40168-023-01656-1

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