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Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019
Uveitis is a process of intraocular inflammation that may involve different sections of the uveal tract. Apart from systemic or localized immune-mediated diseases, infections are key players in the etiology of uveitis and entail different treatment strategies. Rubella virus (RuV) is a recognized cau...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629089/ https://www.ncbi.nlm.nih.gov/pubmed/37932668 http://dx.doi.org/10.1186/s12886-023-03182-y |
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author | Hönemann, Mario Scharfenberg, Elizabeth Dietze, Nadine Claus, Claudia Jochmann, Claudia Liebert, Uwe Gerd |
author_facet | Hönemann, Mario Scharfenberg, Elizabeth Dietze, Nadine Claus, Claudia Jochmann, Claudia Liebert, Uwe Gerd |
author_sort | Hönemann, Mario |
collection | PubMed |
description | Uveitis is a process of intraocular inflammation that may involve different sections of the uveal tract. Apart from systemic or localized immune-mediated diseases, infections are key players in the etiology of uveitis and entail different treatment strategies. Rubella virus (RuV) is a recognized causative agent for the development of Fuchs uveitis, representing a major cause of virus-associated intraocular inflammation. A cohort of 159 patients diagnosed with different forms of uveitis between 2013 and 2019 was subjected to diagnostic antibody testing of the aqueous or vitreous humor. The diagnostic panel included RuV, cytomegalovirus, herpes simplex virus, varicella-zoster virus, and toxoplasmosis. Within this cohort, 38 RuV-associated uveitis (RAU) patients were identified based on a pathologic Goldman-Witmer coefficient indicative of an underlying RuV infection. With a mean age of 45.9 years, the RAU patients were younger than the non-RAU patients (56.3, p < 0.001). The evaluation of clinical parameters revealed a predominance of anterior uveitis and late sequalae such as cataract and glaucoma among the RAU patients. In 15 of the patients a history of prior RuV infections could be confirmed. The study underlines the importance of long-term surveillance of RuV associated diseases that originate from infections before the introduction of RuV vaccination programs. |
format | Online Article Text |
id | pubmed-10629089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106290892023-11-08 Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 Hönemann, Mario Scharfenberg, Elizabeth Dietze, Nadine Claus, Claudia Jochmann, Claudia Liebert, Uwe Gerd BMC Ophthalmol Research Uveitis is a process of intraocular inflammation that may involve different sections of the uveal tract. Apart from systemic or localized immune-mediated diseases, infections are key players in the etiology of uveitis and entail different treatment strategies. Rubella virus (RuV) is a recognized causative agent for the development of Fuchs uveitis, representing a major cause of virus-associated intraocular inflammation. A cohort of 159 patients diagnosed with different forms of uveitis between 2013 and 2019 was subjected to diagnostic antibody testing of the aqueous or vitreous humor. The diagnostic panel included RuV, cytomegalovirus, herpes simplex virus, varicella-zoster virus, and toxoplasmosis. Within this cohort, 38 RuV-associated uveitis (RAU) patients were identified based on a pathologic Goldman-Witmer coefficient indicative of an underlying RuV infection. With a mean age of 45.9 years, the RAU patients were younger than the non-RAU patients (56.3, p < 0.001). The evaluation of clinical parameters revealed a predominance of anterior uveitis and late sequalae such as cataract and glaucoma among the RAU patients. In 15 of the patients a history of prior RuV infections could be confirmed. The study underlines the importance of long-term surveillance of RuV associated diseases that originate from infections before the introduction of RuV vaccination programs. BioMed Central 2023-11-06 /pmc/articles/PMC10629089/ /pubmed/37932668 http://dx.doi.org/10.1186/s12886-023-03182-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hönemann, Mario Scharfenberg, Elizabeth Dietze, Nadine Claus, Claudia Jochmann, Claudia Liebert, Uwe Gerd Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title | Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title_full | Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title_fullStr | Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title_full_unstemmed | Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title_short | Rubella virus-associated uveitis at a tertiary care hospital in Germany between 2013 and 2019 |
title_sort | rubella virus-associated uveitis at a tertiary care hospital in germany between 2013 and 2019 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629089/ https://www.ncbi.nlm.nih.gov/pubmed/37932668 http://dx.doi.org/10.1186/s12886-023-03182-y |
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