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Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in t...

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Autores principales: Boschin, Isabella Merante, Bertazza, Loris, Scaroni, Carla, Mian, Caterina, Pelizzo, Maria Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629113/
https://www.ncbi.nlm.nih.gov/pubmed/37942415
http://dx.doi.org/10.3389/fmed.2023.1231566
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author Boschin, Isabella Merante
Bertazza, Loris
Scaroni, Carla
Mian, Caterina
Pelizzo, Maria Rosa
author_facet Boschin, Isabella Merante
Bertazza, Loris
Scaroni, Carla
Mian, Caterina
Pelizzo, Maria Rosa
author_sort Boschin, Isabella Merante
collection PubMed
description Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated.
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spelling pubmed-106291132023-11-08 Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma Boschin, Isabella Merante Bertazza, Loris Scaroni, Carla Mian, Caterina Pelizzo, Maria Rosa Front Med (Lausanne) Medicine Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10629113/ /pubmed/37942415 http://dx.doi.org/10.3389/fmed.2023.1231566 Text en Copyright © 2023 Boschin, Bertazza, Scaroni, Mian and Pelizzo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Boschin, Isabella Merante
Bertazza, Loris
Scaroni, Carla
Mian, Caterina
Pelizzo, Maria Rosa
Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title_full Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title_fullStr Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title_full_unstemmed Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title_short Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
title_sort sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629113/
https://www.ncbi.nlm.nih.gov/pubmed/37942415
http://dx.doi.org/10.3389/fmed.2023.1231566
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