Cargando…
Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629113/ https://www.ncbi.nlm.nih.gov/pubmed/37942415 http://dx.doi.org/10.3389/fmed.2023.1231566 |
_version_ | 1785131896199446528 |
---|---|
author | Boschin, Isabella Merante Bertazza, Loris Scaroni, Carla Mian, Caterina Pelizzo, Maria Rosa |
author_facet | Boschin, Isabella Merante Bertazza, Loris Scaroni, Carla Mian, Caterina Pelizzo, Maria Rosa |
author_sort | Boschin, Isabella Merante |
collection | PubMed |
description | Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated. |
format | Online Article Text |
id | pubmed-10629113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106291132023-11-08 Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma Boschin, Isabella Merante Bertazza, Loris Scaroni, Carla Mian, Caterina Pelizzo, Maria Rosa Front Med (Lausanne) Medicine Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10629113/ /pubmed/37942415 http://dx.doi.org/10.3389/fmed.2023.1231566 Text en Copyright © 2023 Boschin, Bertazza, Scaroni, Mian and Pelizzo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Boschin, Isabella Merante Bertazza, Loris Scaroni, Carla Mian, Caterina Pelizzo, Maria Rosa Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title | Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title_full | Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title_fullStr | Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title_full_unstemmed | Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title_short | Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
title_sort | sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629113/ https://www.ncbi.nlm.nih.gov/pubmed/37942415 http://dx.doi.org/10.3389/fmed.2023.1231566 |
work_keys_str_mv | AT boschinisabellamerante sentinellymphnodemappingcurrentapplicationsandfutureperspectivesinthyroidcarcinoma AT bertazzaloris sentinellymphnodemappingcurrentapplicationsandfutureperspectivesinthyroidcarcinoma AT scaronicarla sentinellymphnodemappingcurrentapplicationsandfutureperspectivesinthyroidcarcinoma AT miancaterina sentinellymphnodemappingcurrentapplicationsandfutureperspectivesinthyroidcarcinoma AT pelizzomariarosa sentinellymphnodemappingcurrentapplicationsandfutureperspectivesinthyroidcarcinoma |