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The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however, the mechanisms are not entirely cla...

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Autores principales: Li, Na, Wang, Ling, Li, Lei, Yang, Meng-Zhao, Wang, Qing-Xiang, Bai, Xi-Wen, Gao, Feng, Yuan, Yi-Qiang, Yu, Zu-Jiang, Ren, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629124/
https://www.ncbi.nlm.nih.gov/pubmed/37936201
http://dx.doi.org/10.1186/s40779-023-00489-1
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author Li, Na
Wang, Ling
Li, Lei
Yang, Meng-Zhao
Wang, Qing-Xiang
Bai, Xi-Wen
Gao, Feng
Yuan, Yi-Qiang
Yu, Zu-Jiang
Ren, Zhi-Gang
author_facet Li, Na
Wang, Ling
Li, Lei
Yang, Meng-Zhao
Wang, Qing-Xiang
Bai, Xi-Wen
Gao, Feng
Yuan, Yi-Qiang
Yu, Zu-Jiang
Ren, Zhi-Gang
author_sort Li, Na
collection PubMed
description Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however, the mechanisms are not entirely clarified. It is gaining awareness that alterations in the assembly, structure, and dynamics of gut microbiota are intimately engaged in the AF progression. Owing to advancements in next-generation sequencing technologies and computational strategies, researchers can explore novel linkages with the genomes, transcriptomes, proteomes, and metabolomes through parallel meta-omics approaches, rendering a panoramic view of the culture-independent microbial investigation. In this review, we summarized the evidence for a bidirectional correlation between AF and the gut microbiome. Furthermore, we proposed the concept of “gut-immune-heart” axis and addressed the direct and indirect causal roots between the gut microbiome and AF. The intricate relationship was unveiled to generate innovative microbiota-based preventive and therapeutic interventions, which shed light on a definite direction for future experiments.
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spelling pubmed-106291242023-11-08 The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives Li, Na Wang, Ling Li, Lei Yang, Meng-Zhao Wang, Qing-Xiang Bai, Xi-Wen Gao, Feng Yuan, Yi-Qiang Yu, Zu-Jiang Ren, Zhi-Gang Mil Med Res Review Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however, the mechanisms are not entirely clarified. It is gaining awareness that alterations in the assembly, structure, and dynamics of gut microbiota are intimately engaged in the AF progression. Owing to advancements in next-generation sequencing technologies and computational strategies, researchers can explore novel linkages with the genomes, transcriptomes, proteomes, and metabolomes through parallel meta-omics approaches, rendering a panoramic view of the culture-independent microbial investigation. In this review, we summarized the evidence for a bidirectional correlation between AF and the gut microbiome. Furthermore, we proposed the concept of “gut-immune-heart” axis and addressed the direct and indirect causal roots between the gut microbiome and AF. The intricate relationship was unveiled to generate innovative microbiota-based preventive and therapeutic interventions, which shed light on a definite direction for future experiments. BioMed Central 2023-11-07 /pmc/articles/PMC10629124/ /pubmed/37936201 http://dx.doi.org/10.1186/s40779-023-00489-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Na
Wang, Ling
Li, Lei
Yang, Meng-Zhao
Wang, Qing-Xiang
Bai, Xi-Wen
Gao, Feng
Yuan, Yi-Qiang
Yu, Zu-Jiang
Ren, Zhi-Gang
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title_full The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title_fullStr The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title_full_unstemmed The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title_short The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
title_sort correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629124/
https://www.ncbi.nlm.nih.gov/pubmed/37936201
http://dx.doi.org/10.1186/s40779-023-00489-1
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