EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma

Epithelial membrane protein 3 (EMP3) is an N-glycosylated tetraspanin with a putative trafficking function. It is highly expressed in isocitrate dehydrogenase-wild-type glioblastoma (IDH-wt GBM), and its high expression correlates with poor survival. However, the exact trafficking role of EMP3 and h...

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Detalles Bibliográficos
Autores principales: Martija, Antoni Andreu, Krauß, Alexandra, Bächle, Natalie, Doth, Laura, Christians, Arne, Krunic, Damir, Schneider, Martin, Helm, Dominic, Will, Rainer, Hartmann, Christian, Herold-Mende, Christel, von Deimling, Andreas, Pusch, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629159/
https://www.ncbi.nlm.nih.gov/pubmed/37936247
http://dx.doi.org/10.1186/s40478-023-01673-z

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