ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

BACKGROUND: ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic diversion of glucose through the pentose phosphate pathway...

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Detalles Bibliográficos
Autores principales: Terlizzi, Cristina, De Rosa, Viviana, Iommelli, Francesca, Pezone, Antonio, Altobelli, Giovanna G., Maddalena, Maurizio, Dimitrov, Jelena, De Rosa, Caterina, Della Corte, Carminia Maria, Avvedimento, Vittorio Enrico, Del Vecchio, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629204/
https://www.ncbi.nlm.nih.gov/pubmed/37932830
http://dx.doi.org/10.1186/s40170-023-00320-4

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