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A Telescoped Continuous Flow Enantioselective Process for Accessing Intermediates of 1-Aryl-1,3-diols as Chiral Building Blocks

[Image: see text] A telescoped continuous flow process is reported for the enantioselective synthesis of chiral precursors of 1-aryl-1,3-diols, intermediates in the synthesis of ezetimibe, dapoxetine, duloxetine, and atomoxetine. The two-step sequence consists of an asymmetric allylboration of readi...

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Detalles Bibliográficos
Autores principales:	Maestro, Aitor, Nagy, Bence S., Ötvös, Sándor B., Kappe, C. Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629223/ https://www.ncbi.nlm.nih.gov/pubmed/37844195 http://dx.doi.org/10.1021/acs.joc.3c02040

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