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Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study

BACKGROUND: Patient outcome after acute Achilles tendon rupture (ATR) varies and is difficult to predict. Whether early variations in healing, visualized with ultrasonography, can predict long-term patient outcome is unclear. PURPOSE: To (1) examine the associations of Achilles tendon cross-sectiona...

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Autores principales: Saarensilta, Annukka, Aufwerber, Susanna, Grävare Silbernagel, Karin, Ackermann, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629330/
https://www.ncbi.nlm.nih.gov/pubmed/37941888
http://dx.doi.org/10.1177/23259671231205326
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author Saarensilta, Annukka
Aufwerber, Susanna
Grävare Silbernagel, Karin
Ackermann, Paul
author_facet Saarensilta, Annukka
Aufwerber, Susanna
Grävare Silbernagel, Karin
Ackermann, Paul
author_sort Saarensilta, Annukka
collection PubMed
description BACKGROUND: Patient outcome after acute Achilles tendon rupture (ATR) varies and is difficult to predict. Whether early variations in healing, visualized with ultrasonography, can predict long-term patient outcome is unclear. PURPOSE: To (1) examine the associations of Achilles tendon cross-sectional area (CSA) and elongation (TE) during healing of ATR repair with patient outcomes at 12 months postoperatively and (2) investigate the predictive or diagnostic capacity of the morphological biomarkers. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: This study was based on previously collected data from 86 patients who underwent acute standardized ATR repair between 2013 and 2018 and who were included in a prior randomized trial investigating early functional mobilization (EFM). In the EFM group, loading was allowed immediately after surgery, while in the comparison group, loading was allowed first at 2 weeks postoperatively. Achilles tendon CSA and length were measured with ultrasound at 6 weeks, 6 months, and 12 months postoperatively. CSA ratio and absolute difference in the length of the healthy and injured tendons were calculated. Patient-reported outcome was registered with the validated Achilles tendon Total Rupture Score and functional outcome with the heel-rise endurance test at 12 months postoperatively. The limb symmetry index (LSI) was calculated for maximum heel-rise height (HRH(max)) and total concentric work. Multiple linear regression adjusted for age was used, and the area under the receiver operating characteristic curve (AUC) was calculated to evaluate predictive capacity. RESULTS: A larger CSA ratio at 6 weeks was associated with higher LSI HRH(max) at 12 months (R(2), 0.35; P < .001) and exhibited good predictive capacity (AUC, 0.82). More TE at 12 months was associated with lower LSI total concentric work at 12 months (R(2), 0.21; P = .001) and exhibited acceptable predictive capacity (AUC, 0.71). CONCLUSION: Greater Achilles tendon CSA seen on ultrasound 6 weeks after surgical repair had good clinical prediction for long-term functional outcome. TE at 12 months was predictive of inferior functional outcome. REGISTRATION: NCT02318472 (ClinicalTrials.gov identifier).
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spelling pubmed-106293302023-11-08 Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study Saarensilta, Annukka Aufwerber, Susanna Grävare Silbernagel, Karin Ackermann, Paul Orthop J Sports Med Original Research BACKGROUND: Patient outcome after acute Achilles tendon rupture (ATR) varies and is difficult to predict. Whether early variations in healing, visualized with ultrasonography, can predict long-term patient outcome is unclear. PURPOSE: To (1) examine the associations of Achilles tendon cross-sectional area (CSA) and elongation (TE) during healing of ATR repair with patient outcomes at 12 months postoperatively and (2) investigate the predictive or diagnostic capacity of the morphological biomarkers. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: This study was based on previously collected data from 86 patients who underwent acute standardized ATR repair between 2013 and 2018 and who were included in a prior randomized trial investigating early functional mobilization (EFM). In the EFM group, loading was allowed immediately after surgery, while in the comparison group, loading was allowed first at 2 weeks postoperatively. Achilles tendon CSA and length were measured with ultrasound at 6 weeks, 6 months, and 12 months postoperatively. CSA ratio and absolute difference in the length of the healthy and injured tendons were calculated. Patient-reported outcome was registered with the validated Achilles tendon Total Rupture Score and functional outcome with the heel-rise endurance test at 12 months postoperatively. The limb symmetry index (LSI) was calculated for maximum heel-rise height (HRH(max)) and total concentric work. Multiple linear regression adjusted for age was used, and the area under the receiver operating characteristic curve (AUC) was calculated to evaluate predictive capacity. RESULTS: A larger CSA ratio at 6 weeks was associated with higher LSI HRH(max) at 12 months (R(2), 0.35; P < .001) and exhibited good predictive capacity (AUC, 0.82). More TE at 12 months was associated with lower LSI total concentric work at 12 months (R(2), 0.21; P = .001) and exhibited acceptable predictive capacity (AUC, 0.71). CONCLUSION: Greater Achilles tendon CSA seen on ultrasound 6 weeks after surgical repair had good clinical prediction for long-term functional outcome. TE at 12 months was predictive of inferior functional outcome. REGISTRATION: NCT02318472 (ClinicalTrials.gov identifier). SAGE Publications 2023-11-06 /pmc/articles/PMC10629330/ /pubmed/37941888 http://dx.doi.org/10.1177/23259671231205326 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Saarensilta, Annukka
Aufwerber, Susanna
Grävare Silbernagel, Karin
Ackermann, Paul
Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title_full Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title_fullStr Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title_full_unstemmed Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title_short Early Tendon Morphology as a Biomarker of Long-term Patient Outcomes After Surgical Repair of Achilles Tendon Rupture: A Prospective Cohort Study
title_sort early tendon morphology as a biomarker of long-term patient outcomes after surgical repair of achilles tendon rupture: a prospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629330/
https://www.ncbi.nlm.nih.gov/pubmed/37941888
http://dx.doi.org/10.1177/23259671231205326
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