Cargando…
Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery
BACKGROUND: Cervical schwannoma is a rare neoplasm that usually occurs like a nondolent lateral neck mass but when growing and symptomatic requires radical excision. Sodium fluorescein (SF) is a dye that is uptake by schwannomas, which makes it amenable for its use in the resection of difficult or r...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629342/ https://www.ncbi.nlm.nih.gov/pubmed/37941611 http://dx.doi.org/10.25259/SNI_451_2023 |
_version_ | 1785131948439502848 |
---|---|
author | Marrone, Salvatore Sanz, Julio Alberto Andres Cacciotti, Guglielmo Campione, Alberto Boccacci, Fabio Fraschetti, Flavia Iacopino, Domenico Gerardo Mastronardi, Luciano |
author_facet | Marrone, Salvatore Sanz, Julio Alberto Andres Cacciotti, Guglielmo Campione, Alberto Boccacci, Fabio Fraschetti, Flavia Iacopino, Domenico Gerardo Mastronardi, Luciano |
author_sort | Marrone, Salvatore |
collection | PubMed |
description | BACKGROUND: Cervical schwannoma is a rare neoplasm that usually occurs like a nondolent lateral neck mass but when growing and symptomatic requires radical excision. Sodium fluorescein (SF) is a dye that is uptake by schwannomas, which makes it amenable for its use in the resection of difficult or recurrent cases. METHODS: We describe the case of a patient presenting with a recurrence of a vagus nerve schwannoma in the cervical region and the step-by-step technique for its complete microsurgical exeresis helped by the use of SF dye. RESULTS: We achieved a complete microsurgical exeresis, despite the presence of exuberant perilesional fibrosis, by exploiting the ability of SF to stain the schwannoma and nearby tissues. That happens due to altered vascular permeability, allowing us to better differentiate the lesion boundaries and reactive scar tissue under microscope visualization (YELLOW 560 nm filter). CONCLUSION: Recurrent cervical schwannoma might represent a surgical challenge due to its relation to the nerve, main cervical vessels, and the scar tissue encompassing the lesion. Although SF can cross both blood–brain and blood–tumor barriers, the impregnation of neoplastic tissue is still greater than that of nonneoplastic peripheric tissues. Such behavior may facilitate a safer removal of this kind of lesion while respecting contiguous anatomical structures. |
format | Online Article Text |
id | pubmed-10629342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-106293422023-11-08 Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery Marrone, Salvatore Sanz, Julio Alberto Andres Cacciotti, Guglielmo Campione, Alberto Boccacci, Fabio Fraschetti, Flavia Iacopino, Domenico Gerardo Mastronardi, Luciano Surg Neurol Int Technical Notes BACKGROUND: Cervical schwannoma is a rare neoplasm that usually occurs like a nondolent lateral neck mass but when growing and symptomatic requires radical excision. Sodium fluorescein (SF) is a dye that is uptake by schwannomas, which makes it amenable for its use in the resection of difficult or recurrent cases. METHODS: We describe the case of a patient presenting with a recurrence of a vagus nerve schwannoma in the cervical region and the step-by-step technique for its complete microsurgical exeresis helped by the use of SF dye. RESULTS: We achieved a complete microsurgical exeresis, despite the presence of exuberant perilesional fibrosis, by exploiting the ability of SF to stain the schwannoma and nearby tissues. That happens due to altered vascular permeability, allowing us to better differentiate the lesion boundaries and reactive scar tissue under microscope visualization (YELLOW 560 nm filter). CONCLUSION: Recurrent cervical schwannoma might represent a surgical challenge due to its relation to the nerve, main cervical vessels, and the scar tissue encompassing the lesion. Although SF can cross both blood–brain and blood–tumor barriers, the impregnation of neoplastic tissue is still greater than that of nonneoplastic peripheric tissues. Such behavior may facilitate a safer removal of this kind of lesion while respecting contiguous anatomical structures. Scientific Scholar 2023-10-20 /pmc/articles/PMC10629342/ /pubmed/37941611 http://dx.doi.org/10.25259/SNI_451_2023 Text en Copyright: © 2023 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Technical Notes Marrone, Salvatore Sanz, Julio Alberto Andres Cacciotti, Guglielmo Campione, Alberto Boccacci, Fabio Fraschetti, Flavia Iacopino, Domenico Gerardo Mastronardi, Luciano Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title | Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title_full | Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title_fullStr | Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title_full_unstemmed | Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title_short | Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
title_sort | utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery |
topic | Technical Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629342/ https://www.ncbi.nlm.nih.gov/pubmed/37941611 http://dx.doi.org/10.25259/SNI_451_2023 |
work_keys_str_mv | AT marronesalvatore utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT sanzjulioalbertoandres utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT cacciottiguglielmo utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT campionealberto utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT boccaccifabio utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT fraschettiflavia utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT iacopinodomenicogerardo utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery AT mastronardiluciano utilityofsodiumfluoresceininrecurrentcervicalvagusschwannomasurgery |