Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome

INTRODUCTION: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and dysplasia. The gene encoding ten-eleven translocation 2 (tet2), a dioxygenase enzyme that catalyzes the conversion of 5-methylcytosine (...

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Detalles Bibliográficos
Autores principales: Neelamraju, Yaseswini, Gjini, Evisa, Chhangawala, Sagar, Fan, Hao, He, Shuning, Jing, Chang-Bin, Nguyen, Ashley T., Prajapati, Subhash, Sheridan, Caroline, Houvras, Yariv, Melnick, Ari, Look, A. Thomas, Garrett-Bakelman, Francine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629367/
https://www.ncbi.nlm.nih.gov/pubmed/37937078
http://dx.doi.org/10.3389/frhem.2023.1235170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629367/
https://www.ncbi.nlm.nih.gov/pubmed/37937078
http://dx.doi.org/10.3389/frhem.2023.1235170

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