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Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome
INTRODUCTION: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and dysplasia. The gene encoding ten-eleven translocation 2 (tet2), a dioxygenase enzyme that catalyzes the conversion of 5-methylcytosine (...
Autores principales: | Neelamraju, Yaseswini, Gjini, Evisa, Chhangawala, Sagar, Fan, Hao, He, Shuning, Jing, Chang-Bin, Nguyen, Ashley T., Prajapati, Subhash, Sheridan, Caroline, Houvras, Yariv, Melnick, Ari, Look, A. Thomas, Garrett-Bakelman, Francine E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629367/ https://www.ncbi.nlm.nih.gov/pubmed/37937078 http://dx.doi.org/10.3389/frhem.2023.1235170 |
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