Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing

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Eukaryotic DNA replication must occur exactly once per cell cycle to maintain cell ploidy. This outcome is ensured by temporally separating replicative helicase loading (G1 phase) and activation (S phase). In budding yeast, helicase loading is prevented outside of G1 by cyclin-dependent kinase (CDK)...

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Detalles Bibliográficos
Autores principales: Amasino, Audra L., Gupta, Shalini, Friedman, Larry J., Gelles, Jeff, Bell, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629557/
https://www.ncbi.nlm.nih.gov/pubmed/37428921
http://dx.doi.org/10.1073/pnas.2221484120
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