NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis

Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age and joint trauma are prominently associated with OA occurrence, the trigger and signaling pathways propagating their pathogenic aspects are ill defined. Following long-term catabolic activity and trau...

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Detalles Bibliográficos
Autores principales: Shen, Ping, Serve, Sebastian, Wu, Peihua, Liu, Xiaohui, Dai, Yujie, Durán-Hernández, Nayar, Nguyen, Dan Thi Mai, Fuchs, Michael, Maleitzke, Tazio, Reisener, Marie-Jacqueline, Dzamukova, Maria, Nussbaumer, Katrin, Brunner, Tobias M., Li, Yonghai, Holecska, Vivien, Heinz, Gitta A., Heinrich, Frederik, Durek, Pawel, Katsoula, Georgia, Gwinner, Clemens, Jung, Tobias, Zeggini, Eleftheria, Winkler, Tobias, Mashreghi, Mir-Farzin, Pumberger, Matthias, Perka, Carsten, Löhning, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629581/
https://www.ncbi.nlm.nih.gov/pubmed/37428931
http://dx.doi.org/10.1073/pnas.2207993120

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