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Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting

BACKGROUND: SARS-CoV-2 variant evolution and increasing immunity altered the impact of pediatric SARS-CoV-2 infection. Public health decision-making relies on accurate and timely reporting of clinical data. METHODS: This international hospital-based multicenter, prospective cohort study with real-ti...

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Autores principales: Tulling, Adam J., Lugthart, Gertjan, Mooij, Miriam G., Brackel, Caroline L. H., Terheggen-Lagro, Suzanne W. J., Oostenbrink, Rianne, Buysse, Corinne M. P., Hashimoto, Simone, Armbrust, Wineke, Bannier, Michiel A. G. E., Bekhof, Jolita, van Gameren-Oosterom, Helma B., Hendriks, Han, van Houten, Marlies A., van der Linden, Jan W., Lebon, Ankie, van Onzenoort-Bokken, Lonneke, Tramper-Stranders, Gerdien A., van Veen, Mirjam, von Asmuth, Erik G. J., Buddingh, Emilie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629607/
https://www.ncbi.nlm.nih.gov/pubmed/37823702
http://dx.doi.org/10.1097/INF.0000000000004098
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author Tulling, Adam J.
Lugthart, Gertjan
Mooij, Miriam G.
Brackel, Caroline L. H.
Terheggen-Lagro, Suzanne W. J.
Oostenbrink, Rianne
Buysse, Corinne M. P.
Hashimoto, Simone
Armbrust, Wineke
Bannier, Michiel A. G. E.
Bekhof, Jolita
van Gameren-Oosterom, Helma B.
Hendriks, Han
van Houten, Marlies A.
van der Linden, Jan W.
Lebon, Ankie
van Onzenoort-Bokken, Lonneke
Tramper-Stranders, Gerdien A.
van Veen, Mirjam
von Asmuth, Erik G. J.
Buddingh, Emilie P.
author_facet Tulling, Adam J.
Lugthart, Gertjan
Mooij, Miriam G.
Brackel, Caroline L. H.
Terheggen-Lagro, Suzanne W. J.
Oostenbrink, Rianne
Buysse, Corinne M. P.
Hashimoto, Simone
Armbrust, Wineke
Bannier, Michiel A. G. E.
Bekhof, Jolita
van Gameren-Oosterom, Helma B.
Hendriks, Han
van Houten, Marlies A.
van der Linden, Jan W.
Lebon, Ankie
van Onzenoort-Bokken, Lonneke
Tramper-Stranders, Gerdien A.
van Veen, Mirjam
von Asmuth, Erik G. J.
Buddingh, Emilie P.
author_sort Tulling, Adam J.
collection PubMed
description BACKGROUND: SARS-CoV-2 variant evolution and increasing immunity altered the impact of pediatric SARS-CoV-2 infection. Public health decision-making relies on accurate and timely reporting of clinical data. METHODS: This international hospital-based multicenter, prospective cohort study with real-time reporting was active from March 2020 to December 2022. We evaluated longitudinal incident rates and risk factors for disease severity. RESULTS: We included 564 hospitalized children with acute COVID-19 (n = 375) or multisystem inflammatory syndrome in children (n = 189) from the Netherlands, Curaçao and Surinam. In COVID-19, 134/375 patients (36%) needed supplemental oxygen therapy and 35 (9.3%) required intensive care treatment. Age above 12 years and preexisting pulmonary conditions were predictors for severe COVID-19. During omicron, hospitalized children had milder disease. During population immunity, the incidence rate of pediatric COVID-19 infection declined for older children but was stable for children below 1 year. The incidence rate of multisystem inflammatory syndrome in children was highest during the delta wave and has decreased rapidly since omicron emerged. Real-time reporting of our data impacted national pediatric SARS-CoV-2 vaccination- and booster-policies. CONCLUSIONS: Our data supports the notion that similar to adults, prior immunity protects against severe sequelae of SARS-CoV-2 infections in children. Real-time reporting of accurate and high-quality data is feasible and impacts clinical and public health decision-making. The reporting framework of our consortium is readily accessible for future SARS-CoV-2 waves and other emerging infections.
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spelling pubmed-106296072023-11-08 Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting Tulling, Adam J. Lugthart, Gertjan Mooij, Miriam G. Brackel, Caroline L. H. Terheggen-Lagro, Suzanne W. J. Oostenbrink, Rianne Buysse, Corinne M. P. Hashimoto, Simone Armbrust, Wineke Bannier, Michiel A. G. E. Bekhof, Jolita van Gameren-Oosterom, Helma B. Hendriks, Han van Houten, Marlies A. van der Linden, Jan W. Lebon, Ankie van Onzenoort-Bokken, Lonneke Tramper-Stranders, Gerdien A. van Veen, Mirjam von Asmuth, Erik G. J. Buddingh, Emilie P. Pediatr Infect Dis J COVID Reports BACKGROUND: SARS-CoV-2 variant evolution and increasing immunity altered the impact of pediatric SARS-CoV-2 infection. Public health decision-making relies on accurate and timely reporting of clinical data. METHODS: This international hospital-based multicenter, prospective cohort study with real-time reporting was active from March 2020 to December 2022. We evaluated longitudinal incident rates and risk factors for disease severity. RESULTS: We included 564 hospitalized children with acute COVID-19 (n = 375) or multisystem inflammatory syndrome in children (n = 189) from the Netherlands, Curaçao and Surinam. In COVID-19, 134/375 patients (36%) needed supplemental oxygen therapy and 35 (9.3%) required intensive care treatment. Age above 12 years and preexisting pulmonary conditions were predictors for severe COVID-19. During omicron, hospitalized children had milder disease. During population immunity, the incidence rate of pediatric COVID-19 infection declined for older children but was stable for children below 1 year. The incidence rate of multisystem inflammatory syndrome in children was highest during the delta wave and has decreased rapidly since omicron emerged. Real-time reporting of our data impacted national pediatric SARS-CoV-2 vaccination- and booster-policies. CONCLUSIONS: Our data supports the notion that similar to adults, prior immunity protects against severe sequelae of SARS-CoV-2 infections in children. Real-time reporting of accurate and high-quality data is feasible and impacts clinical and public health decision-making. The reporting framework of our consortium is readily accessible for future SARS-CoV-2 waves and other emerging infections. Lippincott Williams & Wilkins 2023-10-12 2023-12 /pmc/articles/PMC10629607/ /pubmed/37823702 http://dx.doi.org/10.1097/INF.0000000000004098 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle COVID Reports
Tulling, Adam J.
Lugthart, Gertjan
Mooij, Miriam G.
Brackel, Caroline L. H.
Terheggen-Lagro, Suzanne W. J.
Oostenbrink, Rianne
Buysse, Corinne M. P.
Hashimoto, Simone
Armbrust, Wineke
Bannier, Michiel A. G. E.
Bekhof, Jolita
van Gameren-Oosterom, Helma B.
Hendriks, Han
van Houten, Marlies A.
van der Linden, Jan W.
Lebon, Ankie
van Onzenoort-Bokken, Lonneke
Tramper-Stranders, Gerdien A.
van Veen, Mirjam
von Asmuth, Erik G. J.
Buddingh, Emilie P.
Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title_full Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title_fullStr Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title_full_unstemmed Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title_short Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
title_sort severe pediatric covid-19 and multisystem inflammatory syndrome in children from wild-type to population immunity: a prospective multicenter cohort study with real-time reporting
topic COVID Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629607/
https://www.ncbi.nlm.nih.gov/pubmed/37823702
http://dx.doi.org/10.1097/INF.0000000000004098
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