Centrosome amplification promotes cell invasion via cell–cell contact disruption and Rap-1 activation

Centrosome amplification (CA) is a prominent feature of human cancers linked to tumorigenesis in vivo. Here, we report mechanistic contributions of CA induction alone to tumour architecture and extracellular matrix (ECM) remodelling. CA induction in non-tumorigenic breast cells MCF10A causes cell mi...

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Detalles Bibliográficos
Autores principales: Prakash, Anu, Paunikar, Shishir, Webber, Mark, McDermott, Emma, Vellanki, Sri H., Thompson, Kerry, Dockery, Peter, Jahns, Hanne, Brown, James A. L., Hopkins, Ann M., Bourke, Emer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629695/
https://www.ncbi.nlm.nih.gov/pubmed/37772773
http://dx.doi.org/10.1242/jcs.261150

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