HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective prov...

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Detalles Bibliográficos
Autores principales: Benner, Sarah E, Zhu, Xianming, Hussain, Sarah, Florman, Sander, Eby, Yolanda, Fernandez, Reinaldo E, Ostrander, Darin, Rana, Meenakshi, Ottmann, Shane, Hand, Jonathan, Price, Jennifer C, Pereira, Marcus R, Wojciechowski, David, Simkins, Jacques, Stosor, Valentina, Mehta, Sapna A, Aslam, Saima, Malinis, Maricar, Haidar, Ghady, Massie, Allan, Smith, Melissa L, Odim, Jonah, Morsheimer, Megan, Quinn, Thomas C, Laird, Gregory M, Siliciano, Robert, Balagopal, Ashwin, Segev, Dorry L, Durand, Christine M, Redd, Andrew D, Tobian, Aaron A R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629701/
https://www.ncbi.nlm.nih.gov/pubmed/37379584
http://dx.doi.org/10.1093/infdis/jiad241
Descripción
Sumario:The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.

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