The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle

While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, h...

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Autores principales: Formenti, Fabio, Cortés, Alba, Deiana, Michela, Salter, Susannah, Parkhill, Julian, Berriman, Matt, Rinaldi, Gabriel, Cantacessi, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629713/
https://www.ncbi.nlm.nih.gov/pubmed/37487539
http://dx.doi.org/10.1093/infdis/jiad288
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author Formenti, Fabio
Cortés, Alba
Deiana, Michela
Salter, Susannah
Parkhill, Julian
Berriman, Matt
Rinaldi, Gabriel
Cantacessi, Cinzia
author_facet Formenti, Fabio
Cortés, Alba
Deiana, Michela
Salter, Susannah
Parkhill, Julian
Berriman, Matt
Rinaldi, Gabriel
Cantacessi, Cinzia
author_sort Formenti, Fabio
collection PubMed
description While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies
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spelling pubmed-106297132023-11-08 The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle Formenti, Fabio Cortés, Alba Deiana, Michela Salter, Susannah Parkhill, Julian Berriman, Matt Rinaldi, Gabriel Cantacessi, Cinzia J Infect Dis Brief Report While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies Oxford University Press 2023-07-24 /pmc/articles/PMC10629713/ /pubmed/37487539 http://dx.doi.org/10.1093/infdis/jiad288 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Formenti, Fabio
Cortés, Alba
Deiana, Michela
Salter, Susannah
Parkhill, Julian
Berriman, Matt
Rinaldi, Gabriel
Cantacessi, Cinzia
The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title_full The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title_fullStr The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title_full_unstemmed The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title_short The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle
title_sort human blood fluke, schistosoma mansoni, harbors bacteria throughout the parasite's life cycle
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629713/
https://www.ncbi.nlm.nih.gov/pubmed/37487539
http://dx.doi.org/10.1093/infdis/jiad288
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