Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins

Ruxolitinib is a cornerstone of management for some subsets of myeloproliferative neoplasms (MPNs); however, a considerable number of patients respond suboptimally. Here, we evaluated the efficacy of micheliolide (MCL), a natural guaianolide sesquiterpene lactone, alone or in combination with ruxoli...

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Detalles Bibliográficos
Autores principales: Huang, Huijun, Liu, Jinqin, Yang, Lin, Yan, Yiru, Chen, Meng, Li, Bing, Xu, Zefeng, Qin, Tiejun, Qu, Shiqiang, Wang, Liang, Huang, Gang, Chen, Yue, Xiao, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
https://www.ncbi.nlm.nih.gov/pubmed/37941916
http://dx.doi.org/10.1097/BS9.0000000000000168

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