Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration

Cortical cell loss is a core feature of Huntington’s disease (HD), beginning many years before clinical motor diagnosis, during the premanifest stage. However, it is unclear how genetic topography relates to cortical cell loss. Here, we explore the biological processes and cell types underlying this...

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Detalles Bibliográficos
Autores principales: Estevez-Fraga, Carlos, Altmann, Andre, Parker, Christopher S, Scahill, Rachael I, Costa, Beatrice, Chen, Zhongbo, Manzoni, Claudia, Zarkali, Angeliki, Durr, Alexandra, Roos, Raymund A C, Landwehrmeyer, Bernhard, Leavitt, Blair R, Rees, Geraint, Tabrizi, Sarah J, McColgan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629790/
https://www.ncbi.nlm.nih.gov/pubmed/37587097
http://dx.doi.org/10.1093/brain/awad275

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