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Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome
INTRODUCTION: Tumor lysis syndrome (TLS) is an oncologic emergency characterized by several metabolic derangements, such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. TLS is typically observed in hematologic malignancies, especially after starting the first administration of a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629853/ https://www.ncbi.nlm.nih.gov/pubmed/37942403 http://dx.doi.org/10.1159/000534398 |
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author | Im, Daebin Alsheimer, Katie Poulose, Joyson Zeykan, Violeta Talamo, Giampaolo |
author_facet | Im, Daebin Alsheimer, Katie Poulose, Joyson Zeykan, Violeta Talamo, Giampaolo |
author_sort | Im, Daebin |
collection | PubMed |
description | INTRODUCTION: Tumor lysis syndrome (TLS) is an oncologic emergency characterized by several metabolic derangements, such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. TLS is typically observed in hematologic malignancies, especially after starting the first administration of antineoplastic therapies. TLS in a solid malignancy is very unusual, and exceedingly rare when occurring spontaneously, in the absence of chemotherapy. CASE PRESENTATION: We report a case of a 76-year-old man with lung adenocarcinoma, which started as a cancer with indolent behavior and small tumor burden but relapsed in 5 months with rapidly proliferating metastatic disease. Spontaneous TLS was the presenting clinical manifestation of the tumor relapse, and it led to the patient’s death. CONCLUSION: To our knowledge, this is the first case of spontaneous TLS in a relapsed adenocarcinoma of the lung reported in the medical literature. The development of the metabolic derangements of TLS should prompt the consideration of tumor relapse during the follow-up of patients with solid malignancies. |
format | Online Article Text |
id | pubmed-10629853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-106298532023-11-08 Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome Im, Daebin Alsheimer, Katie Poulose, Joyson Zeykan, Violeta Talamo, Giampaolo Case Rep Oncol Case Report INTRODUCTION: Tumor lysis syndrome (TLS) is an oncologic emergency characterized by several metabolic derangements, such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. TLS is typically observed in hematologic malignancies, especially after starting the first administration of antineoplastic therapies. TLS in a solid malignancy is very unusual, and exceedingly rare when occurring spontaneously, in the absence of chemotherapy. CASE PRESENTATION: We report a case of a 76-year-old man with lung adenocarcinoma, which started as a cancer with indolent behavior and small tumor burden but relapsed in 5 months with rapidly proliferating metastatic disease. Spontaneous TLS was the presenting clinical manifestation of the tumor relapse, and it led to the patient’s death. CONCLUSION: To our knowledge, this is the first case of spontaneous TLS in a relapsed adenocarcinoma of the lung reported in the medical literature. The development of the metabolic derangements of TLS should prompt the consideration of tumor relapse during the follow-up of patients with solid malignancies. S. Karger AG 2023-11-06 /pmc/articles/PMC10629853/ /pubmed/37942403 http://dx.doi.org/10.1159/000534398 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Im, Daebin Alsheimer, Katie Poulose, Joyson Zeykan, Violeta Talamo, Giampaolo Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title | Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title_full | Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title_fullStr | Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title_full_unstemmed | Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title_short | Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome |
title_sort | relapse of lung adenocarcinoma manifested by spontaneous tumor lysis syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629853/ https://www.ncbi.nlm.nih.gov/pubmed/37942403 http://dx.doi.org/10.1159/000534398 |
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