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Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)

Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family of cell adhesion molecules (CAMs), which partic...

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Autores principales: Ortega-Gascó, Alba, Parcerisas, Antoni, Hino, Keiko, Herranz-Pérez, Vicente, Ulloa, Fausto, Elias-Tersa, Alba, Bosch, Miquel, García-Verdugo, José Manuel, Simó, Sergi, Pujadas, Lluís, Soriano, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629901/
https://www.ncbi.nlm.nih.gov/pubmed/37724425
http://dx.doi.org/10.1093/cercor/bhad340
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author Ortega-Gascó, Alba
Parcerisas, Antoni
Hino, Keiko
Herranz-Pérez, Vicente
Ulloa, Fausto
Elias-Tersa, Alba
Bosch, Miquel
García-Verdugo, José Manuel
Simó, Sergi
Pujadas, Lluís
Soriano, Eduardo
author_facet Ortega-Gascó, Alba
Parcerisas, Antoni
Hino, Keiko
Herranz-Pérez, Vicente
Ulloa, Fausto
Elias-Tersa, Alba
Bosch, Miquel
García-Verdugo, José Manuel
Simó, Sergi
Pujadas, Lluís
Soriano, Eduardo
author_sort Ortega-Gascó, Alba
collection PubMed
description Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family of cell adhesion molecules (CAMs), which participate in signal transduction and regulate the survival, division, and differentiation of radial glial progenitors (RGPs). Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during corticogenesis. We characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus, revealing different levels of NCAM2 amid the progression of RGPs and the formation of neurons. We showed that Ncam2 overexpression in adult mice arrested progenitors in an RGP-like state, affecting the normal course of young-adult neurogenesis. Furthermore, changes in Ncam2 levels during corticogenesis led to transient migratory deficits but did not affect the survival and proliferation of RGPs, suggesting a differential role of NCAM2 in adult and embryonic stages. Our data reinforce the relevance of CAMs in the neurogenic process by revealing a significant role of Ncam2 levels in the regulation of RGPs during young-adult neurogenesis in the hippocampus.
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spelling pubmed-106299012023-11-08 Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2) Ortega-Gascó, Alba Parcerisas, Antoni Hino, Keiko Herranz-Pérez, Vicente Ulloa, Fausto Elias-Tersa, Alba Bosch, Miquel García-Verdugo, José Manuel Simó, Sergi Pujadas, Lluís Soriano, Eduardo Cereb Cortex Original Article Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family of cell adhesion molecules (CAMs), which participate in signal transduction and regulate the survival, division, and differentiation of radial glial progenitors (RGPs). Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during corticogenesis. We characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus, revealing different levels of NCAM2 amid the progression of RGPs and the formation of neurons. We showed that Ncam2 overexpression in adult mice arrested progenitors in an RGP-like state, affecting the normal course of young-adult neurogenesis. Furthermore, changes in Ncam2 levels during corticogenesis led to transient migratory deficits but did not affect the survival and proliferation of RGPs, suggesting a differential role of NCAM2 in adult and embryonic stages. Our data reinforce the relevance of CAMs in the neurogenic process by revealing a significant role of Ncam2 levels in the regulation of RGPs during young-adult neurogenesis in the hippocampus. Oxford University Press 2023-09-18 /pmc/articles/PMC10629901/ /pubmed/37724425 http://dx.doi.org/10.1093/cercor/bhad340 Text en © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Ortega-Gascó, Alba
Parcerisas, Antoni
Hino, Keiko
Herranz-Pérez, Vicente
Ulloa, Fausto
Elias-Tersa, Alba
Bosch, Miquel
García-Verdugo, José Manuel
Simó, Sergi
Pujadas, Lluís
Soriano, Eduardo
Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title_full Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title_fullStr Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title_full_unstemmed Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title_short Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
title_sort regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (ncam2)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629901/
https://www.ncbi.nlm.nih.gov/pubmed/37724425
http://dx.doi.org/10.1093/cercor/bhad340
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