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The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis
Amiodarone-induced thyrotoxicosis (AIT) can be difficult to treat since amiodarone's long half-life leads to a persistent effect on thyroid function. We present a case of a 74-year-old male with severe AIT who presented with altered mentation and ultimately required intubation and intensive car...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629971/ https://www.ncbi.nlm.nih.gov/pubmed/37942132 http://dx.doi.org/10.1210/jcemcr/luad123 |
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author | Moazezi, Tina Koh, Chung-Kay |
author_facet | Moazezi, Tina Koh, Chung-Kay |
author_sort | Moazezi, Tina |
collection | PubMed |
description | Amiodarone-induced thyrotoxicosis (AIT) can be difficult to treat since amiodarone's long half-life leads to a persistent effect on thyroid function. We present a case of a 74-year-old male with severe AIT who presented with altered mentation and ultimately required intubation and intensive care for management of thyroid storm. Standard medical therapy for treatment of thyroid storm was initiated immediately, but the patient remained unresponsive with worsening biochemical parameters with increasing total T3 levels and sustained elevated levels of free T4 after 5 days of medical management. Due to the lack of a clinical and biochemical response to conventional medical therapy, the patient was started on plasmapheresis and underwent a total of 7 cycles of plasmapheresis over a period of 10 days. He significantly improved with plasmapheresis and was successfully bridged to a total thyroidectomy, which was completed without complications. |
format | Online Article Text |
id | pubmed-10629971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106299712023-11-08 The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis Moazezi, Tina Koh, Chung-Kay JCEM Case Rep Case Report Amiodarone-induced thyrotoxicosis (AIT) can be difficult to treat since amiodarone's long half-life leads to a persistent effect on thyroid function. We present a case of a 74-year-old male with severe AIT who presented with altered mentation and ultimately required intubation and intensive care for management of thyroid storm. Standard medical therapy for treatment of thyroid storm was initiated immediately, but the patient remained unresponsive with worsening biochemical parameters with increasing total T3 levels and sustained elevated levels of free T4 after 5 days of medical management. Due to the lack of a clinical and biochemical response to conventional medical therapy, the patient was started on plasmapheresis and underwent a total of 7 cycles of plasmapheresis over a period of 10 days. He significantly improved with plasmapheresis and was successfully bridged to a total thyroidectomy, which was completed without complications. Oxford University Press 2023-11-03 /pmc/articles/PMC10629971/ /pubmed/37942132 http://dx.doi.org/10.1210/jcemcr/luad123 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Moazezi, Tina Koh, Chung-Kay The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title | The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title_full | The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title_fullStr | The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title_full_unstemmed | The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title_short | The Use of Plasmapheresis in a Severe Case of Amiodarone-Induced Thyrotoxicosis |
title_sort | use of plasmapheresis in a severe case of amiodarone-induced thyrotoxicosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629971/ https://www.ncbi.nlm.nih.gov/pubmed/37942132 http://dx.doi.org/10.1210/jcemcr/luad123 |
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