Cargando…

InCliniGene enables high-throughput and comprehensive in vivo clonal tracking toward clinical genomics data integration

High-throughput clonal tracking in patients under hematopoietic stem cell gene therapy with integrating vector is instrumental in assessing bio-safety and efficacy. Monitoring the fate of millions of transplanted clones and their progeny across differentiation and proliferation over time leverages t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merelli, Ivan, Beretta, Stefano, Cesana, Daniela, Gennari, Alessandro, Benedicenti, Fabrizio, Spinozzi, Giulio, Cesini, Daniele, Montini, Eugenio, D’Agostino, Daniele, Calabria, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630073/ https://www.ncbi.nlm.nih.gov/pubmed/37935583 http://dx.doi.org/10.1093/database/baad069

Ejemplares similares

ISAnalytics enables longitudinal and high-throughput clonal tracking studies in hematopoietic stem cell gene therapy applications
por: Pais, Giulia, et al.
Publicado: (2022)

VISPA2: a scalable pipeline for high-throughput identification and annotation of vector integration sites
por: Spinozzi, Giulio, et al.
Publicado: (2017)

adLIMS: a customized open source software that allows bridging clinical and basic molecular research studies
por: Calabria, Andrea, et al.
Publicado: (2015)

γ-TRIS: a graph-algorithm for comprehensive identification of vector genomic insertion sites
por: Calabria, Andrea, et al.
Publicado: (2020)

VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites
por: Calabria, Andrea, et al.
Publicado: (2014)

Clini-Data : la historia clínica completa
por: Rodríguez R., A. Arturo
Publicado: (2005)

Cloud Infrastructures for In Silico Drug Discovery: Economic and Practical Aspects
por: D'Agostino, Daniele, et al.
Publicado: (2013)

Editorial: Heterogeneous Computing for AI and Big Data in High Energy Physics
por: D’Agostino, Daniele, et al.
Publicado: (2021)

Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice
por: Calabria, Andrea, et al.
Publicado: (2023)

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings
por: Petrillo, Carolina, et al.
Publicado: (2019)

Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo
por: Wagner, Sebastian, et al.
Publicado: (2022)

Assessing the impact of lentiviral vector integration on splicing of cellular genes at the genome-wide level
por: Montini, Eugenio, et al.
Publicado: (2011)

CliniProteus: A flexible clinical trials information management system
por: Mathura, Venkatarajan S, et al.
Publicado: (2007)

Robust Selections of Various Hematopoietic Cell Fractions on the CliniMACS Plus Instrument
por: Panch, Sandhya R., et al.
Publicado: (2019)

Normalization of clonal diversity in gene therapy studies using shape constrained splines
por: Del Core, L., et al.
Publicado: (2022)

Advantages of using graph databases to explore chromatin conformation capture experiments
por: D’Agostino, Daniele, et al.
Publicado: (2021)

Managing, Analysing, and Integrating Big Data in Medical Bioinformatics: Open Problems and Future Perspectives
por: Merelli, Ivan, et al.
Publicado: (2014)

High-Performance Computing and Big Data in Omics-Based Medicine
por: Merelli, Ivan, et al.
Publicado: (2014)

HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
por: Cesana, Daniela, et al.
Publicado: (2017)

GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy
por: Fernández, Lucía, et al.
Publicado: (2019)

High performance workflow implementation for protein surface characterization using grid technology
por: Merelli, Ivan, et al.
Publicado: (2005)

Development of CliniPup, a Serious Game Aimed at Reducing Perioperative Anxiety and Pain in Children: Mixed Methods Study
por: Verschueren, Sarah, et al.
Publicado: (2019)

Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system
por: Zhang, Wei, et al.
Publicado: (2018)

A Web-Based Serious Game for Health to Reduce Perioperative Anxiety and Pain in Children (CliniPup): Pilot Randomized Controlled Trial
por: Buffel, Connor, et al.
Publicado: (2019)

Parallel Solutions for Voxel-Based Simulations of Reaction-Diffusion Systems
por: D'Agostino, Daniele, et al.
Publicado: (2014)

High-throughput transcriptomics
por: D’Agostino, Nunzio, et al.
Publicado: (2022)

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
por: Biavasco, Riccardo, et al.
Publicado: (2021)

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
por: Ferrari, Samuele, et al.
Publicado: (2022)

Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy
por: Lattanzi, Annalisa, et al.
Publicado: (2014)

Non-Invasive Preoperative Imaging Differential Diagnosis of Intracranial Hemangiopericytoma and Angiomatous Meningioma: A Novel Developed and Validated Multiparametric MRI-Based Clini-Radiomic Model
por: Fan, Yanghua, et al.
Publicado: (2022)

Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform
por: Magnani, Chiara F., et al.
Publicado: (2016)

Structural–Functional Relationship of the Ribonucleolytic Activity of aIF5A from Sulfolobus solfataricus
por: Romagnoli, Alice, et al.
Publicado: (2022)

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer
por: Ranzani, Marco, et al.
Publicado: (2013)

Enabling HPC systems for HEP: the INFN-CINECA Experience
por: Boccali, Tommaso, et al.
Publicado: (2021)

Aseismic transient during the 2010–2014 seismic swarm: evidence for longer recurrence of M ≥ 6.5 earthquakes in the Pollino gap (Southern Italy)?
por: Cheloni, Daniele, et al.
Publicado: (2017)

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking
por: Ferrari, Samuele, et al.
Publicado: (2020)

Utilities for High-Throughput Analysis of B-Cell Clonal Lineages
por: Lees, William D., et al.
Publicado: (2015)

RNA secondary structure factorization in prime tangles
por: Marchei, Daniele, et al.
Publicado: (2022)

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
por: Schiroli, Giulia, et al.
Publicado: (2019)

A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation
por: D’Agostino, Vito G., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_a1c13ml435bpd6mbahhtrplftk