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Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center
BACKGROUND AND PURPOSE: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. MATERIALS AND METHODS: Patient recruitment numbers in prospective clinical studies of solid...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630114/ http://dx.doi.org/10.1016/j.neo.2023.100946 |
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author | von der Grün, Jens Ahmadsei, Maiwand Breyer, Isabel Britschgi, Christian Eberli, Daniel Hermanns, Thomas Mangana, Joanna Petrowsky, Henrik Ramelyte, Egle Roth, Patrick Schär, Gabriel Opitz, Isabelle Weller, Michael Wicki, Andreas Witzel, Isabell Balermpas, Panagiotis Guckenberger, Matthias |
author_facet | von der Grün, Jens Ahmadsei, Maiwand Breyer, Isabel Britschgi, Christian Eberli, Daniel Hermanns, Thomas Mangana, Joanna Petrowsky, Henrik Ramelyte, Egle Roth, Patrick Schär, Gabriel Opitz, Isabelle Weller, Michael Wicki, Andreas Witzel, Isabell Balermpas, Panagiotis Guckenberger, Matthias |
author_sort | von der Grün, Jens |
collection | PubMed |
description | BACKGROUND AND PURPOSE: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. MATERIALS AND METHODS: Patient recruitment numbers in prospective clinical studies of solid malignancies were retrospectively analyzed for the years 2019 – 2021 at the Comprehensive Cancer Center Zurich (CCCZ). Changes in recruitment numbers were tested for association with organ-specific subunits, as well as organizational and treatment-related trial characteristics. To assess differences between categorical variables, Chi-squared test was used. For uni- and multivariate analysis, Cox proportional hazards were calculated. RESULTS: In 2019, there were a total of 107 studies (registry trials, clinical phase I-III trials, and translational studies) recruiting 304 patients at the CCCZ. During the COVID-19 pandemic in 2020 and 2021, there were 120 and 125 active trials with a total recruitment of 355 and 666 patients, respectively. No significant differences between the subunits and study characteristics in changes of patient recruitment in clinical phase I-III trials were identified when the year prior to the COVID-19 pandemic (2019) was compared to the first year of the pandemic (2020) and to 2020-2021. CONCLUSIONS: Despite healthcare systems around the world have experienced significant disruption due to the COVID-19 pandemic, data from our tertiary cancer center showed that clinical trial activities were maintained at a high level during the pandemic. |
format | Online Article Text |
id | pubmed-10630114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106301142023-11-10 Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center von der Grün, Jens Ahmadsei, Maiwand Breyer, Isabel Britschgi, Christian Eberli, Daniel Hermanns, Thomas Mangana, Joanna Petrowsky, Henrik Ramelyte, Egle Roth, Patrick Schär, Gabriel Opitz, Isabelle Weller, Michael Wicki, Andreas Witzel, Isabell Balermpas, Panagiotis Guckenberger, Matthias Neoplasia Original article BACKGROUND AND PURPOSE: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. MATERIALS AND METHODS: Patient recruitment numbers in prospective clinical studies of solid malignancies were retrospectively analyzed for the years 2019 – 2021 at the Comprehensive Cancer Center Zurich (CCCZ). Changes in recruitment numbers were tested for association with organ-specific subunits, as well as organizational and treatment-related trial characteristics. To assess differences between categorical variables, Chi-squared test was used. For uni- and multivariate analysis, Cox proportional hazards were calculated. RESULTS: In 2019, there were a total of 107 studies (registry trials, clinical phase I-III trials, and translational studies) recruiting 304 patients at the CCCZ. During the COVID-19 pandemic in 2020 and 2021, there were 120 and 125 active trials with a total recruitment of 355 and 666 patients, respectively. No significant differences between the subunits and study characteristics in changes of patient recruitment in clinical phase I-III trials were identified when the year prior to the COVID-19 pandemic (2019) was compared to the first year of the pandemic (2020) and to 2020-2021. CONCLUSIONS: Despite healthcare systems around the world have experienced significant disruption due to the COVID-19 pandemic, data from our tertiary cancer center showed that clinical trial activities were maintained at a high level during the pandemic. Neoplasia Press 2023-10-27 /pmc/articles/PMC10630114/ http://dx.doi.org/10.1016/j.neo.2023.100946 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original article von der Grün, Jens Ahmadsei, Maiwand Breyer, Isabel Britschgi, Christian Eberli, Daniel Hermanns, Thomas Mangana, Joanna Petrowsky, Henrik Ramelyte, Egle Roth, Patrick Schär, Gabriel Opitz, Isabelle Weller, Michael Wicki, Andreas Witzel, Isabell Balermpas, Panagiotis Guckenberger, Matthias Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title | Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title_full | Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title_fullStr | Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title_full_unstemmed | Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title_short | Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center |
title_sort | patient recruitment into clinical studies of solid malignancies during the covid-19 pandemic in a tertiary cancer center |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630114/ http://dx.doi.org/10.1016/j.neo.2023.100946 |
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