Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Engineered transactivation domains (TADs) combined with programmable DNA binding platforms have revolutionized synthetic transcriptional control. Despite recent progress in programmable CRISPR–Cas-based transactivation (CRISPRa) technologies, the TADs used in these systems often contain poorly toler...

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Detalles Bibliográficos
Autores principales: Mahata, Barun, Cabrera, Alan, Brenner, Daniel A., Guerra-Resendez, Rosa Selenia, Li, Jing, Goell, Jacob, Wang, Kaiyuan, Guo, Yannie, Escobar, Mario, Parthasarathy, Abinand Krishna, Szadowski, Hailey, Bedford, Guy, Reed, Daniel R., Kim, Sunghwan, Hilton, Isaac B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630135/
https://www.ncbi.nlm.nih.gov/pubmed/37813990
http://dx.doi.org/10.1038/s41592-023-02036-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630135/
https://www.ncbi.nlm.nih.gov/pubmed/37813990
http://dx.doi.org/10.1038/s41592-023-02036-1

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