Cargando…
Between but Not Within-Species Variation in the Distribution of Fitness Effects
New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is, therefore, of vital interest in evolutionary biology. Recent work has uncovered striking similariti...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630145/ https://www.ncbi.nlm.nih.gov/pubmed/37832225 http://dx.doi.org/10.1093/molbev/msad228 |
_version_ | 1785132094077272064 |
---|---|
author | James, Jennifer Kastally, Chedly Budde, Katharina B González-Martínez, Santiago C Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin |
author_facet | James, Jennifer Kastally, Chedly Budde, Katharina B González-Martínez, Santiago C Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin |
author_sort | James, Jennifer |
collection | PubMed |
description | New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is, therefore, of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, that is whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterized the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence, and genetic background. We find statistical support for the presence of variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and those evolutionarily recent events, such as demographic changes and local adaptation, have little impact. |
format | Online Article Text |
id | pubmed-10630145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106301452023-10-13 Between but Not Within-Species Variation in the Distribution of Fitness Effects James, Jennifer Kastally, Chedly Budde, Katharina B González-Martínez, Santiago C Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin Mol Biol Evol Discoveries New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is, therefore, of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, that is whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterized the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence, and genetic background. We find statistical support for the presence of variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and those evolutionarily recent events, such as demographic changes and local adaptation, have little impact. Oxford University Press 2023-10-13 /pmc/articles/PMC10630145/ /pubmed/37832225 http://dx.doi.org/10.1093/molbev/msad228 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Discoveries James, Jennifer Kastally, Chedly Budde, Katharina B González-Martínez, Santiago C Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title | Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title_full | Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title_fullStr | Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title_full_unstemmed | Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title_short | Between but Not Within-Species Variation in the Distribution of Fitness Effects |
title_sort | between but not within-species variation in the distribution of fitness effects |
topic | Discoveries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630145/ https://www.ncbi.nlm.nih.gov/pubmed/37832225 http://dx.doi.org/10.1093/molbev/msad228 |
work_keys_str_mv | AT jamesjennifer betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT kastallychedly betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT buddekatharinab betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT gonzalezmartinezsantiagoc betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT milesipascal betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT pyhajarvitanja betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT lascouxmartin betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects AT betweenbutnotwithinspeciesvariationinthedistributionoffitnesseffects |