ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model

ARL6IP1 is implicated in hereditary spastic paraplegia (HSP), but the specific pathogenic mechanism leading to neurodegeneration has not been elucidated. Here, we clarified the molecular mechanism of ARL6IP1 in HSP using in vitro and in vivo models. The Arl6ip1 knockout (KO) mouse model was generate...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Jung Hwa, Kang, Hyun Mi, Kim, Dae Hun, Jeong, Bohyeon, Lee, Da Yong, Lee, Jae-Ran, Baek, Jeong Yeob, Cho, Hyun-Soo, Son, Mi-Young, Kim, Dae Soo, Kim, Nam-Soon, Jung, Cho-Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630151/
https://www.ncbi.nlm.nih.gov/pubmed/37934410
http://dx.doi.org/10.1084/jem.20230367

Ejemplares similares

Ejemplares similares