Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease (AD) post-mortem brain tissue and in experime...

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Detalles Bibliográficos
Autores principales: Ribeiro, Felipe C., Cozachenco, Danielle, Heimfarth, Luana, Fortuna, Juliana T. S., de Freitas, Guilherme B., de Sousa, Jorge M., Alves-Leon, Soniza V., Leite, Renata E. P., Suemoto, Claudia K., Grinberg, Lea T., De Felice, Fernanda G., Lourenco, Mychael V., Ferreira, Sergio T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630330/
https://www.ncbi.nlm.nih.gov/pubmed/37935829
http://dx.doi.org/10.1038/s42003-023-05511-9

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