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Conformational plasticity and allosteric communication networks explain Shelterin protein TPP1 binding to human telomerase

The Shelterin complex protein TPP1 interacts with human telomerase (TERT) by means of the TEL-patch region, controlling telomere homeostasis. Aberrations in the TPP1-TERT heterodimer formation might lead to short telomeres and severe diseases like dyskeratosis congenita and Hoyeraal-Hreidarsson synd...

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Detalles Bibliográficos
Autores principales:	Aureli, Simone, Cardenas, Vince Bart, Raniolo, Stefano, Limongelli, Vittorio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630336/ https://www.ncbi.nlm.nih.gov/pubmed/37935941 http://dx.doi.org/10.1038/s42004-023-01040-y

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