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Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse

Retinal degenerative diseases (RDDs) are a diverse group of retinal disorders that cause visual impairment. While RDD prevalence is high, little is known about the molecular mechanisms underlying the pathogenesis within many of these disorders. Here we use transcriptome analysis to elucidate the mol...

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Autores principales: Cistulli, Rebecca, Miller, Jonathan G., Enke, Ray A., Walker, Marquis T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630596/
https://www.ncbi.nlm.nih.gov/pubmed/38020430
http://dx.doi.org/10.1016/j.dib.2023.109659
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author Cistulli, Rebecca
Miller, Jonathan G.
Enke, Ray A.
Walker, Marquis T.
author_facet Cistulli, Rebecca
Miller, Jonathan G.
Enke, Ray A.
Walker, Marquis T.
author_sort Cistulli, Rebecca
collection PubMed
description Retinal degenerative diseases (RDDs) are a diverse group of retinal disorders that cause visual impairment. While RDD prevalence is high, little is known about the molecular mechanisms underlying the pathogenesis within many of these disorders. Here we use transcriptome analysis to elucidate the molecular mechanisms that drive early onset photoreceptor neuron function loss in the mouse model of the RDD Mucolipidosis type IV (MLIV). MLIV is a lysosomal storage disorder resulting from loss of function mutations in the MCOLN1 gene. MCOLN1 encodes a lysosomal cation channel, the transient receptor potential channel mucolipin 1 (Trpml1). To identify changes in gene expression during onset in MLIV we used a genetic mouse model (Mcoln1(−/−)) which recapitulates clinical attributes of the human disease. We conducted transcriptome analysis in 6-week old control and Mcoln1(−/−) mice under normal 12:12 light cycle as well as low and high light stress conditions. These data will be valuable to the vision research community for identifying differentially expressed in early onset MLIV potentially leading to new insights into the pathophysiology of this RDD. Raw FASTQ files and processed counts files for the RNA-seq libraries are deposited in the NCBI Sequence Read Archive (SRA) and have been assigned BioProject accession PRJNA1002601 [1].
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spelling pubmed-106305962023-10-15 Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse Cistulli, Rebecca Miller, Jonathan G. Enke, Ray A. Walker, Marquis T. Data Brief Data Article Retinal degenerative diseases (RDDs) are a diverse group of retinal disorders that cause visual impairment. While RDD prevalence is high, little is known about the molecular mechanisms underlying the pathogenesis within many of these disorders. Here we use transcriptome analysis to elucidate the molecular mechanisms that drive early onset photoreceptor neuron function loss in the mouse model of the RDD Mucolipidosis type IV (MLIV). MLIV is a lysosomal storage disorder resulting from loss of function mutations in the MCOLN1 gene. MCOLN1 encodes a lysosomal cation channel, the transient receptor potential channel mucolipin 1 (Trpml1). To identify changes in gene expression during onset in MLIV we used a genetic mouse model (Mcoln1(−/−)) which recapitulates clinical attributes of the human disease. We conducted transcriptome analysis in 6-week old control and Mcoln1(−/−) mice under normal 12:12 light cycle as well as low and high light stress conditions. These data will be valuable to the vision research community for identifying differentially expressed in early onset MLIV potentially leading to new insights into the pathophysiology of this RDD. Raw FASTQ files and processed counts files for the RNA-seq libraries are deposited in the NCBI Sequence Read Archive (SRA) and have been assigned BioProject accession PRJNA1002601 [1]. Elsevier 2023-10-15 /pmc/articles/PMC10630596/ /pubmed/38020430 http://dx.doi.org/10.1016/j.dib.2023.109659 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Cistulli, Rebecca
Miller, Jonathan G.
Enke, Ray A.
Walker, Marquis T.
Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title_full Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title_fullStr Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title_full_unstemmed Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title_short Transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, Mcoln1(−/−) mouse
title_sort transcriptome dataset of light-dependent expression in the early onset retinal degeneration model, mcoln1(−/−) mouse
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630596/
https://www.ncbi.nlm.nih.gov/pubmed/38020430
http://dx.doi.org/10.1016/j.dib.2023.109659
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