The prognostic impact of SIGLEC5-induced impairment of CD8(+) T cell activation in sepsis

BACKGROUND: Sepsis is associated with T-cell exhaustion, which significantly reduces patient outcomes. Therefore, targeting of immune checkpoints (ICs) is deemed necessary for effective sepsis management. Here, we evaluated the role of SIGLEC5 as an IC ligand and explored its potential as a biomarke...

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Detalles Bibliográficos
Autores principales: Lozano-Rodríguez, Roberto, Avendaño-Ortíz, José, Montalbán-Hernández, Karla, Ruiz-Rodríguez, Juan Carlos, Ferrer, Ricardo, Martín-Quirós, Alejandro, Maroun-Eid, Charbel, González-López, Juan José, Fàbrega, Anna, Terrón-Arcos, Verónica, Gutiérrez-Fernández, María, Alonso-López, Elisa, Cubillos-Zapata, Carolina, Fernández-Velasco, María, Pérez de Diego, Rebeca, Pelegrin, Pablo, García-Palenciano, Carlos, Cueto, Francisco J., del Fresno, Carlos, López-Collazo, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630607/
https://www.ncbi.nlm.nih.gov/pubmed/37890368
http://dx.doi.org/10.1016/j.ebiom.2023.104841

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