Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2–ERK depending on downregulation of proteasome-related genes

Wilm’s tumor 1–associating protein (WTAP), a regulatory protein of the m(6)A methyltransferase complex, has been found to play a role in regulating various physiological and pathological processes. However, the in vivo role of WTAP in the pathogenesis of hepatocellular carcinoma (HCC) is unknown. In...

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Detalles Bibliográficos
Autores principales: Li, Xinzhi, Liu, Chunhong, Zhang, Zhimin, Li, Xueying, Yao, Zhicheng, Dong, Yanbin, Wang, Xin, Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630636/
https://www.ncbi.nlm.nih.gov/pubmed/37777158
http://dx.doi.org/10.1016/j.jbc.2023.105301

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