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Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study
OBJECTIVE: To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout. DESIGN: This study used two-sample Mendelian Randomisation (MR). To select the OA genetic instruments, we used...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630649/ https://www.ncbi.nlm.nih.gov/pubmed/38025156 http://dx.doi.org/10.1016/j.ocarto.2023.100414 |
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author | Thompson, Will Swain, Subhashisa Zhao, Sizheng Steven Kamps, Anne Coupland, Carol Kuo, Changfu Bierma-Zeinstra, Sita Runhaar, Jos Doherty, Michael Zhang, Weiya |
author_facet | Thompson, Will Swain, Subhashisa Zhao, Sizheng Steven Kamps, Anne Coupland, Carol Kuo, Changfu Bierma-Zeinstra, Sita Runhaar, Jos Doherty, Michael Zhang, Weiya |
author_sort | Thompson, Will |
collection | PubMed |
description | OBJECTIVE: To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout. DESIGN: This study used two-sample Mendelian Randomisation (MR). To select the OA genetic instruments, we used data from the largest recent genome-wide association study (GWAS) of OA (GO Consortium), with a focus on OA of the knee (62,497 cases, 333,557 controls), hip (35,445 cases, 316,943 controls) and hand (20,901 cases, 282,881 controls). Genetic associations for comorbidities were selected from GWAS for depression (246,363 cases, 561,190 controls), tiredness (449,019 participants), multisite chronic pain (387,649 participants), IBS (53,400 cases, 433,201 controls) and gout (6543 cases, 456,390 controls). We performed a bidirectional MR analysis using the inverse variance weighted method, for both joint specific and overall OA. RESULTS: Hip OA had a causal effect on multisite chronic pain (per unit change 0.02, 95% CI 0.01 to 0.04). Multisite chronic pain had a causal effect on knee (odd ratio (OR) 2.74, 95% CI 2.20 to 3.41), hip (OR 2.12, 95% CI 1.54 to 2.92), hand (OR 2.24, 95% CI 1.59 to 3.16) and overall OA (OR 2.44, 95% CI, 2.06 to 2.86). In addition, depression and tiredness had causal effects on knee and hand, but not hip, OA. CONCLUSIONS: Apart from Hip OA to multisite chronic pain, other joint OA did not have causal effects on these comorbidities. In contrast, multisite chronic pain had a causal effect on any painful OA. |
format | Online Article Text |
id | pubmed-10630649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106306492023-10-21 Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study Thompson, Will Swain, Subhashisa Zhao, Sizheng Steven Kamps, Anne Coupland, Carol Kuo, Changfu Bierma-Zeinstra, Sita Runhaar, Jos Doherty, Michael Zhang, Weiya Osteoarthr Cartil Open ORIGINAL PAPER OBJECTIVE: To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout. DESIGN: This study used two-sample Mendelian Randomisation (MR). To select the OA genetic instruments, we used data from the largest recent genome-wide association study (GWAS) of OA (GO Consortium), with a focus on OA of the knee (62,497 cases, 333,557 controls), hip (35,445 cases, 316,943 controls) and hand (20,901 cases, 282,881 controls). Genetic associations for comorbidities were selected from GWAS for depression (246,363 cases, 561,190 controls), tiredness (449,019 participants), multisite chronic pain (387,649 participants), IBS (53,400 cases, 433,201 controls) and gout (6543 cases, 456,390 controls). We performed a bidirectional MR analysis using the inverse variance weighted method, for both joint specific and overall OA. RESULTS: Hip OA had a causal effect on multisite chronic pain (per unit change 0.02, 95% CI 0.01 to 0.04). Multisite chronic pain had a causal effect on knee (odd ratio (OR) 2.74, 95% CI 2.20 to 3.41), hip (OR 2.12, 95% CI 1.54 to 2.92), hand (OR 2.24, 95% CI 1.59 to 3.16) and overall OA (OR 2.44, 95% CI, 2.06 to 2.86). In addition, depression and tiredness had causal effects on knee and hand, but not hip, OA. CONCLUSIONS: Apart from Hip OA to multisite chronic pain, other joint OA did not have causal effects on these comorbidities. In contrast, multisite chronic pain had a causal effect on any painful OA. Elsevier 2023-10-21 /pmc/articles/PMC10630649/ /pubmed/38025156 http://dx.doi.org/10.1016/j.ocarto.2023.100414 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | ORIGINAL PAPER Thompson, Will Swain, Subhashisa Zhao, Sizheng Steven Kamps, Anne Coupland, Carol Kuo, Changfu Bierma-Zeinstra, Sita Runhaar, Jos Doherty, Michael Zhang, Weiya Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title | Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title_full | Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title_fullStr | Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title_full_unstemmed | Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title_short | Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study |
title_sort | causal association between subtypes of osteoarthritis and common comorbidities: a mendelian randomisation study |
topic | ORIGINAL PAPER |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630649/ https://www.ncbi.nlm.nih.gov/pubmed/38025156 http://dx.doi.org/10.1016/j.ocarto.2023.100414 |
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