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Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in solid tumors. One major challenge is the shortage of tumor-selective...
Autores principales: | Yuan, Yuncang, Fan, Jiawei, Liang, Dandan, Wang, Shijie, Luo, Xu, Zhu, Yongjie, Liu, Nan, Xiang, Tingxiu, Zhao, Xudong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630660/ https://www.ncbi.nlm.nih.gov/pubmed/37897831 http://dx.doi.org/10.1016/j.tranon.2023.101803 |
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