To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT

Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of Mycobacterium tuberculosis DNA in the absence of viable bacteria. We present a case with two episodes of previous TB. Despite workup including trace...

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Detalles Bibliográficos
Autores principales: Günther, Gunar, Abu- Hussain, Nebal, Keller, Peter M., Guler, Reto, Mukasa, Sandra L., Wolmarans, Karen, Thienemann, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630663/
https://www.ncbi.nlm.nih.gov/pubmed/38025249
http://dx.doi.org/10.1016/j.rmcr.2023.101932
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author Günther, Gunar
Abu- Hussain, Nebal
Keller, Peter M.
Guler, Reto
Mukasa, Sandra L.
Wolmarans, Karen
Thienemann, Friedrich
author_facet Günther, Gunar
Abu- Hussain, Nebal
Keller, Peter M.
Guler, Reto
Mukasa, Sandra L.
Wolmarans, Karen
Thienemann, Friedrich
author_sort Günther, Gunar
collection PubMed
description Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of Mycobacterium tuberculosis DNA in the absence of viable bacteria. We present a case with two episodes of previous TB. Despite workup including trace to low positive PCR results, after performing sputum analysis, bronchoalveolar lavage analysis, cyto-brush and 18F-FDG PET/CT guided transthoracic biopsy, no culturable mycobacteria were detected. 18F-FDG PET/CT showed a high metabolic activity of the biopsied lesions. More accurate strategies and tools in patients with previous TB and positive PCR results are required to make appropriate treatment decisions.
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spelling pubmed-106306632023-10-19 To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT Günther, Gunar Abu- Hussain, Nebal Keller, Peter M. Guler, Reto Mukasa, Sandra L. Wolmarans, Karen Thienemann, Friedrich Respir Med Case Rep Case Report Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of Mycobacterium tuberculosis DNA in the absence of viable bacteria. We present a case with two episodes of previous TB. Despite workup including trace to low positive PCR results, after performing sputum analysis, bronchoalveolar lavage analysis, cyto-brush and 18F-FDG PET/CT guided transthoracic biopsy, no culturable mycobacteria were detected. 18F-FDG PET/CT showed a high metabolic activity of the biopsied lesions. More accurate strategies and tools in patients with previous TB and positive PCR results are required to make appropriate treatment decisions. Elsevier 2023-10-19 /pmc/articles/PMC10630663/ /pubmed/38025249 http://dx.doi.org/10.1016/j.rmcr.2023.101932 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Günther, Gunar
Abu- Hussain, Nebal
Keller, Peter M.
Guler, Reto
Mukasa, Sandra L.
Wolmarans, Karen
Thienemann, Friedrich
To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title_full To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title_fullStr To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title_full_unstemmed To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title_short To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT
title_sort to treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18f-fdg pet/ct
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630663/
https://www.ncbi.nlm.nih.gov/pubmed/38025249
http://dx.doi.org/10.1016/j.rmcr.2023.101932
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