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The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial

PURPOSE: The clinical effect of neoadjuvant intravesical instillation of chemotherapy immediately before transurethral resection of bladder tumors (TURBT) has been a subject of recent research. The aim of this study was to assess the effect of immediate neoadjuvant electromotive instillation of mito...

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Autores principales: El Azab, Abdalla, Abdelbary, Ahmed, El Faqeh M. Okasha, Aly, Aboulkassem, Hatem, Saad Zaghloul, Ashraf, Mohamed Karkeet, Riham, Abdelrahman, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630691/
https://www.ncbi.nlm.nih.gov/pubmed/37932566
http://dx.doi.org/10.4111/icu.20230161
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author El Azab, Abdalla
Abdelbary, Ahmed
El Faqeh M. Okasha, Aly
Aboulkassem, Hatem
Saad Zaghloul, Ashraf
Mohamed Karkeet, Riham
Abdelrahman, Ibrahim
author_facet El Azab, Abdalla
Abdelbary, Ahmed
El Faqeh M. Okasha, Aly
Aboulkassem, Hatem
Saad Zaghloul, Ashraf
Mohamed Karkeet, Riham
Abdelrahman, Ibrahim
author_sort El Azab, Abdalla
collection PubMed
description PURPOSE: The clinical effect of neoadjuvant intravesical instillation of chemotherapy immediately before transurethral resection of bladder tumors (TURBT) has been a subject of recent research. The aim of this study was to assess the effect of immediate neoadjuvant electromotive instillation of mitomycin C before transurethral resection for patients with non-muscle-invasive urothelial bladder cancer. MATERIALS AND METHODS: Our study was a randomized clinical trial carried out on 50 patients diagnosed with non-muscle-invasive urothelial bladder cancer. Patients were classified into two groups: Group I consisted of 25 patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT and intravesical bacille Calmette–Guerin (BCG) per week for 6 weeks; Group II consisted of 25 patients who were treated with TURBT followed by intravesical BCG per week for 6 weeks alone (standard of care). Patients were followed up at 3, 6, 12, and 18 months by cystoscopy. RESULTS: Patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT in combination with BCG had a low recurrence rate compared with those who received BCG alone (12.0% vs. 48.0%, respectively; p=0.012) and a longer disease-free interval (88.0% vs. 52.0%, respectively; p=0.012). Four patients developed progression to muscle-invasive disease (16.0%) in the BCG alone group. However, this difference was not statistically significant (p=0.516). Regarding adverse effects, there were no statistically significant differences between the groups. CONCLUSIONS: Neoadjuvant intravesical electromotive drug administration of mitomycin C before TURBT is safe; reduces recurrence rates and enhances the disease-free interval compared with TURBT followed by BCG alone.
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spelling pubmed-106306912023-11-15 The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial El Azab, Abdalla Abdelbary, Ahmed El Faqeh M. Okasha, Aly Aboulkassem, Hatem Saad Zaghloul, Ashraf Mohamed Karkeet, Riham Abdelrahman, Ibrahim Investig Clin Urol Original Article PURPOSE: The clinical effect of neoadjuvant intravesical instillation of chemotherapy immediately before transurethral resection of bladder tumors (TURBT) has been a subject of recent research. The aim of this study was to assess the effect of immediate neoadjuvant electromotive instillation of mitomycin C before transurethral resection for patients with non-muscle-invasive urothelial bladder cancer. MATERIALS AND METHODS: Our study was a randomized clinical trial carried out on 50 patients diagnosed with non-muscle-invasive urothelial bladder cancer. Patients were classified into two groups: Group I consisted of 25 patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT and intravesical bacille Calmette–Guerin (BCG) per week for 6 weeks; Group II consisted of 25 patients who were treated with TURBT followed by intravesical BCG per week for 6 weeks alone (standard of care). Patients were followed up at 3, 6, 12, and 18 months by cystoscopy. RESULTS: Patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT in combination with BCG had a low recurrence rate compared with those who received BCG alone (12.0% vs. 48.0%, respectively; p=0.012) and a longer disease-free interval (88.0% vs. 52.0%, respectively; p=0.012). Four patients developed progression to muscle-invasive disease (16.0%) in the BCG alone group. However, this difference was not statistically significant (p=0.516). Regarding adverse effects, there were no statistically significant differences between the groups. CONCLUSIONS: Neoadjuvant intravesical electromotive drug administration of mitomycin C before TURBT is safe; reduces recurrence rates and enhances the disease-free interval compared with TURBT followed by BCG alone. The Korean Urological Association 2023-11 2023-10-25 /pmc/articles/PMC10630691/ /pubmed/37932566 http://dx.doi.org/10.4111/icu.20230161 Text en © The Korean Urological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
El Azab, Abdalla
Abdelbary, Ahmed
El Faqeh M. Okasha, Aly
Aboulkassem, Hatem
Saad Zaghloul, Ashraf
Mohamed Karkeet, Riham
Abdelrahman, Ibrahim
The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title_full The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title_fullStr The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title_full_unstemmed The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title_short The effect of immediate neoadjuvant electromotive instillation of mitomycin C with Bacillus Calmette–Guérin versus BCG alone in non-muscle-invasive bladder cancer: A randomized controlled trial
title_sort effect of immediate neoadjuvant electromotive instillation of mitomycin c with bacillus calmette–guérin versus bcg alone in non-muscle-invasive bladder cancer: a randomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630691/
https://www.ncbi.nlm.nih.gov/pubmed/37932566
http://dx.doi.org/10.4111/icu.20230161
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