Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report

Remimazolam is a novel benzodiazepine known for its short-acting properties. The safe use of flumazenil antagonism following remimazolam infusion remains a subject of debate. We present a case of monitored anesthesia care managed to be safe through low-dose remimazolam infusion and flumazenil antago...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamata, Kotoe, Masui, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Anesthesiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630703/
https://www.ncbi.nlm.nih.gov/pubmed/38021893
http://dx.doi.org/10.7759/cureus.46728
_version_ 1785132208368910336
author Kamata, Kotoe
Masui, Kenichi
author_facet Kamata, Kotoe
Masui, Kenichi
author_sort Kamata, Kotoe
collection PubMed
description Remimazolam is a novel benzodiazepine known for its short-acting properties. The safe use of flumazenil antagonism following remimazolam infusion remains a subject of debate. We present a case of monitored anesthesia care managed to be safe through low-dose remimazolam infusion and flumazenil antagonism. Pharmacokinetic simulations revealed that low-dose remimazolam was practically useful as one of the components of multimodal sedation/analgesia. Subsequent sedation with the readministration of remimazolam after a dose of flumazenil could also be attained.
format Online
Article
Text
id pubmed-10630703
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-106307032023-10-09 Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report Kamata, Kotoe Masui, Kenichi Cureus Anesthesiology Remimazolam is a novel benzodiazepine known for its short-acting properties. The safe use of flumazenil antagonism following remimazolam infusion remains a subject of debate. We present a case of monitored anesthesia care managed to be safe through low-dose remimazolam infusion and flumazenil antagonism. Pharmacokinetic simulations revealed that low-dose remimazolam was practically useful as one of the components of multimodal sedation/analgesia. Subsequent sedation with the readministration of remimazolam after a dose of flumazenil could also be attained. Cureus 2023-10-09 /pmc/articles/PMC10630703/ /pubmed/38021893 http://dx.doi.org/10.7759/cureus.46728 Text en Copyright © 2023, Kamata et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Anesthesiology
Kamata, Kotoe
Masui, Kenichi
Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title_full Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title_fullStr Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title_full_unstemmed Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title_short Monitored Anesthesia Care Under a Combination of Low-Dose Remimazolam Infusion and Flumazenil Antagonism: A Case Report
title_sort monitored anesthesia care under a combination of low-dose remimazolam infusion and flumazenil antagonism: a case report
topic Anesthesiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630703/
https://www.ncbi.nlm.nih.gov/pubmed/38021893
http://dx.doi.org/10.7759/cureus.46728
work_keys_str_mv AT kamatakotoe monitoredanesthesiacareunderacombinationoflowdoseremimazolaminfusionandflumazenilantagonismacasereport
AT masuikenichi monitoredanesthesiacareunderacombinationoflowdoseremimazolaminfusionandflumazenilantagonismacasereport

Ejemplares similares