Cargando…
Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon
The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanism of dand...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630811/ https://www.ncbi.nlm.nih.gov/pubmed/37970386 http://dx.doi.org/10.1002/fsn3.3653 |
_version_ | 1785146042531971072 |
---|---|
author | Wang, Shuo Wu, Ping Fan, Zongqiang He, Xingrui Liu, Jinqian Li, Ming Chen, Fang |
author_facet | Wang, Shuo Wu, Ping Fan, Zongqiang He, Xingrui Liu, Jinqian Li, Ming Chen, Fang |
author_sort | Wang, Shuo |
collection | PubMed |
description | The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanism of dandelion polysaccharide (DP) on dextran sulfate sodium (DSS)‐induced colitis in mice. Our results showed that oral administration of DP could dramatically alleviate colonic lesions, as evidenced by reduced DAI scores, shortening of colon length, and ameliorating pathologic abnormalities in colons. Additionally, the expressions of pro‐inflammatory factors (TNF‐α, IL‐1β, and IL‐6) and the infiltration of inflammation‐regulation cells, marked by myeloperoxidase and F4/80, were also inhibited after DP treatment. Moreover, DP treatment also markedly suppressed the nuclear translocation of NF‐κB‐p65 and the activation of the NLRP3 inflammasome. Furthermore, DP also activated the Nrf2/HO‐1 pathway and reduced the oxidative stress induced by DSS. Overall, these results suggest that DP could be a promising novel therapeutic approach for the treatment of UC. |
format | Online Article Text |
id | pubmed-10630811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106308112023-11-15 Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon Wang, Shuo Wu, Ping Fan, Zongqiang He, Xingrui Liu, Jinqian Li, Ming Chen, Fang Food Sci Nutr Original Articles The treatment of ulcerative colitis (UC) is still an intractable medical problem. Polysaccharides are promising candidates for the treatment of UC and have received widespread attention in recent years. The objective of this study was to explore the protective effect and underlying mechanism of dandelion polysaccharide (DP) on dextran sulfate sodium (DSS)‐induced colitis in mice. Our results showed that oral administration of DP could dramatically alleviate colonic lesions, as evidenced by reduced DAI scores, shortening of colon length, and ameliorating pathologic abnormalities in colons. Additionally, the expressions of pro‐inflammatory factors (TNF‐α, IL‐1β, and IL‐6) and the infiltration of inflammation‐regulation cells, marked by myeloperoxidase and F4/80, were also inhibited after DP treatment. Moreover, DP treatment also markedly suppressed the nuclear translocation of NF‐κB‐p65 and the activation of the NLRP3 inflammasome. Furthermore, DP also activated the Nrf2/HO‐1 pathway and reduced the oxidative stress induced by DSS. Overall, these results suggest that DP could be a promising novel therapeutic approach for the treatment of UC. John Wiley and Sons Inc. 2023-09-19 /pmc/articles/PMC10630811/ /pubmed/37970386 http://dx.doi.org/10.1002/fsn3.3653 Text en © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wang, Shuo Wu, Ping Fan, Zongqiang He, Xingrui Liu, Jinqian Li, Ming Chen, Fang Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title_full | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title_fullStr | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title_full_unstemmed | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title_short | Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon |
title_sort | dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing nf‐κb/nlrp3 inflammasome‐mediated inflammation and activating nrf2 in mouse colon |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630811/ https://www.ncbi.nlm.nih.gov/pubmed/37970386 http://dx.doi.org/10.1002/fsn3.3653 |
work_keys_str_mv | AT wangshuo dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT wuping dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT fanzongqiang dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT hexingrui dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT liujinqian dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT liming dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon AT chenfang dandelionpolysaccharidetreatmentprotectsagainstdextransodiumsulfateinducedcolitisbysuppressingnfkbnlrp3inflammasomemediatedinflammationandactivatingnrf2inmousecolon |