DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation

In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post‐absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical tri...

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Detalles Bibliográficos
Autores principales: Sharma, Anand Kumar, Wolfrum, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630880/
https://www.ncbi.nlm.nih.gov/pubmed/37789773
http://dx.doi.org/10.15252/emmm.202318209
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author Sharma, Anand Kumar
Wolfrum, Christian
author_facet Sharma, Anand Kumar
Wolfrum, Christian
author_sort Sharma, Anand Kumar
collection PubMed
description In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post‐absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.[Image: see text]
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spelling pubmed-106308802023-11-15 DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation Sharma, Anand Kumar Wolfrum, Christian EMBO Mol Med Correspondence In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post‐absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.[Image: see text] John Wiley and Sons Inc. 2023-10-04 /pmc/articles/PMC10630880/ /pubmed/37789773 http://dx.doi.org/10.15252/emmm.202318209 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correspondence
Sharma, Anand Kumar
Wolfrum, Christian
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title_full DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title_fullStr DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title_full_unstemmed DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title_short DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation
title_sort dgat inhibition at the post‐absorptive phase reduces plasma fa by increasing fa oxidation
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630880/
https://www.ncbi.nlm.nih.gov/pubmed/37789773
http://dx.doi.org/10.15252/emmm.202318209
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AT wolfrumchristian dgatinhibitionatthepostabsorptivephasereducesplasmafabyincreasingfaoxidation

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